Ozkul Ayca, Meteoglu Ibrahim, Tataroglu Cengiz, Akyol Ali
Medicine Faculty Neurology Department, Adnan Menderes University, Aydin, Turkey.
J Neurooncol. 2007 Jan;81(1):75-9. doi: 10.1007/s11060-006-9208-z. Epub 2006 Nov 1.
Primary diffuse leptomeningeal oligodendrogliomatosis is a rare malignancy of central nervous system without evidence of a primary intraparenchymal focus. We present a 25-year-old woman with the postmortem diagnosis of primary diffuse leptomeningeal oligodendrogliomatosis. She was paraplegic and had sensory loss at the level of thoracal 8-9 for nearly 15 months. There was no symptom due to increased intracranial pressure. Unexpectedly she died just before biopsy. Autopsy revealed a nodular lesion at the level of thoracal 10 vertebra and diffuse oligodendroglioma throughout the leptomeninges of the brain and spine without intraaxial focus. To our knowledge, this is the first case of primary diffuse leptomeningeal oligodendrogliomatosis causing sudden death in the literature.
原发性弥漫性软脑膜少突胶质细胞瘤病是一种罕见的中枢神经系统恶性肿瘤，无原发性脑实质内病灶证据。我们报告一名25岁女性，经尸检诊断为原发性弥漫性软脑膜少突胶质细胞瘤病。她截瘫，胸8-9水平感觉丧失近15个月。无颅内压升高症状。意外的是，她在活检前死亡。尸检发现胸10椎体水平有一个结节性病变，脑和脊髓的软脑膜弥漫性少突胶质细胞瘤，无轴内病灶。据我们所知，这是文献中首例原发性弥漫性软脑膜少突胶质细胞瘤病导致猝死的病例。
