Jørgensen N, Müller J, Giwercman A, Visfeldt J, Møller H, Skakkebaek N E
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
J Pathol. 1995 Jul;176(3):269-78. doi: 10.1002/path.1711760309.
The origin of testicular germ cell tumours occurring during childhood is poorly understood. In adults, the classical seminomas and non-seminomas originate from carcinoma in situ of the testis, which can usually also be detected in seminiferous tubules adjacent to the tumours. In order to contribute with information regarding a possible association between carcinoma in situ and the childhood group of germ cell tumours, we investigated seminiferous tubules adjacent to 13 infantile yolk sac tumours, five infantile teratomas, and six adolescent germ cell tumours of various types, using morphological evaluation, immunohistochemical staining with markers for carcinoma in situ cells, and densitometric DNA measurement of the germ cells. We detected clear differences between the germ cell populations adjacent to adolescent and infantile germ cell tumours. The former were associated with both normal germ cells and carcinoma in situ cells, like germ cell tumours occurring in adult men. Although we were in doubt in two cases, the infantile cell germ cell tumours were in general not associated with carcinoma in situ cells. The aetiology of infantile yolk sac tumours and teratomas may therefore be fundamentally different from that of adolescent and adult germ cell tumours. The origin of yolk sac tumours and teratomas remains to be elucidated.
儿童期发生的睾丸生殖细胞肿瘤的起源尚不清楚。在成年人中，经典的精原细胞瘤和非精原细胞瘤起源于睾丸原位癌，通常也能在肿瘤附近的生精小管中检测到。为了提供有关原位癌与儿童期生殖细胞肿瘤之间可能关联的信息，我们对13例婴儿卵黄囊瘤、5例婴儿畸胎瘤和6例不同类型的青少年生殖细胞肿瘤附近的生精小管进行了研究，采用形态学评估、用原位癌细胞标志物进行免疫组化染色以及对生殖细胞进行光密度DNA测量。我们发现青少年和婴儿生殖细胞肿瘤附近的生殖细胞群体存在明显差异。前者与正常生殖细胞和原位癌细胞均有关联，就像成年男性发生的生殖细胞肿瘤一样。尽管有两例情况我们存在疑问，但婴儿生殖细胞肿瘤总体上与原位癌细胞无关。因此，婴儿卵黄囊瘤和畸胎瘤的病因可能与青少年和成年生殖细胞肿瘤的病因根本不同。卵黄囊瘤和畸胎瘤的起源仍有待阐明。
