Visfeldt J, Jørgensen N, Müller J, Møller H, Skakkebaek N E
University Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
J Pathol. 1994 Sep;174(1):39-47. doi: 10.1002/path.1711740107.
In the Danish Cancer Registry, 72 testicular tumours in boys younger than 15 years of age were recorded during the period 1943-1989 and material from 34 of these was retrieved from Danish departments of pathology. The histological types were evaluated and the role of immunohistochemical staining was analysed. The survival of the patients was correlated with the histological diagnoses, and changes in the incidence of testicular cancers in childhood were analysed. Twenty-nine of the 34 patients had germ cell tumours, which fell into two groups (infantile and pubertal) with distinct differences. The tumours of infancy usually presented before the age of 3 years and were either pure yolk sac tumours or teratomas. The tumours of puberty showed no morphological or immunohistochemical differences from adult germ cell tumours. In the infantile group, immunohistochemical staining confirmed the morphological evaluation but was not necessary for diagnosis. Patients in the infantile group seemed to have a better prognosis than adult patients, only one patient dying from his disease, whereas the pubertal patients seemed to have a prognosis similar to that of adult patients. The incidence of infantile testicular cancer in Denmark appears to have increased at almost the same rate as that observed in adult men, but due to the small numbers in infancy, this cannot be statistically substantiated. We conclude that the testicular germ cell tumours of infancy and puberty may arise from different precursor cells, but both groups seem to arise prenatally.
在丹麦癌症登记处，1943年至1989年期间记录了72例15岁以下男孩的睾丸肿瘤，其中34例的材料取自丹麦各病理科。对组织学类型进行了评估，并分析了免疫组化染色的作用。将患者的生存率与组织学诊断相关联，并分析了儿童期睾丸癌发病率的变化。34例患者中有29例患有生殖细胞肿瘤，可分为两组（婴儿期和青春期），两组有明显差异。婴儿期肿瘤通常在3岁前出现，要么是单纯卵黄囊瘤，要么是畸胎瘤。青春期肿瘤在形态学或免疫组化方面与成人生殖细胞肿瘤无差异。在婴儿期组中，免疫组化染色证实了形态学评估，但对诊断并非必需。婴儿期组的患者预后似乎比成年患者好，只有1例患者死于该病，而青春期患者的预后似乎与成年患者相似。丹麦婴儿期睾丸癌的发病率似乎与成年男性的发病率以几乎相同的速度上升，但由于婴儿期病例数较少，这一点无法从统计学上得到证实。我们得出结论，婴儿期和青春期的睾丸生殖细胞肿瘤可能起源于不同的前体细胞，但两组似乎都在产前发生。
