[大肠癌细胞中PCNA、EGFR、c-erbB-2和p53的免疫组织化学研究]
[Immunohistochemical study of PCNA, EGFR, c-erbB-2 and p53 in carcinomas of large intestine].
作者信息
Yamagiwa H, Onishi N, Onishi T, Onishi T, Onishi H, Watanabe K, Kadowaki Y, Nishii M, Kato Y
机构信息
Department of Pathology, Mie University Hospital, Tsu.
出版信息
Rinsho Byori. 1995 Jul;43(7):703-7.
Immunohistochemical stainings for EGFR, c-erbB-2, p53 and PCNA were performed on 36 and 30 cases of intramucosal and advanced carcinomas of large intestine. Positive rate was 58.3%, 41.6%, 58.3% and 60.6% for EGFR, c-erbB-2, p53 and PCNA in the intramucosal cases, and 66.7%, 50%, 66.7% and 72.6% in the advanced ones, respectively. Relationship between EGFR and c-drbB-2 was more significant in the advanced carcinomas than that in the intramucosal ones. It seemed likely that relationship between p53 and c-erbB-2 was more significant than that between p53 and EGFR. Positive rate of PCNA was of intimate relationship among that of EGFR, c-erbB-2 and p53, and the positive rate increased in the advanced carcinomas.
对36例大肠黏膜内癌和30例进展期癌进行了表皮生长因子受体（EGFR）、c-erbB-2、p53和增殖细胞核抗原（PCNA）的免疫组化染色。EGFR、c-erbB-2、p53和PCNA在黏膜内癌病例中的阳性率分别为58.3%、41.6%、58.3%和60.6%，在进展期癌中分别为66.7%、50%、66.7%和72.6%。EGFR与c-drbB-2之间的关系在进展期癌中比在黏膜内癌中更显著。p53与c-erbB-2之间的关系似乎比p53与EGFR之间的关系更显著。PCNA的阳性率与EGFR、c-erbB-2和p53的阳性率密切相关，且在进展期癌中阳性率升高。
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