[99mTc-MIBI和123I-BMIPP心肌单光子发射计算机断层扫描心电图门控双同位素成像在缺血性心脏病患者中的应用]
[ECG-gated dual isotope myocardial SPECT with 99mTc-MIBI and 123I-BMIPP in patients with ischemic heart disease].
作者信息
Kumita S, Mizumura S, Kijima T, Machida M, Kumazaki T, Tetsuou Y, Sakai S, Kusama Y, Munakata K
机构信息
Department of Radiology, Nippon Medical School, Tokyo.
出版信息
Kaku Igaku. 1995 Jun;32(6):547-55.
Simultaneous dual-isotope SPECT with 99mTc-methoxy isobutyl isonitrile (MIBI) and 123I-beta-methyl iodophenyl-pentadecanoic acid (BMIPP) was performed in 25 patients with ischemic heart disease. ECG-gated myocardial SPECT was acquired following the injection of MIBI (555 MBq) and BMIPP (148 MBq). Both MIBI and BMIPP scans provided high-quality myocardial images. Then, myocardial count increase rate (%WT = ES-ED/ED x 100) was calculated as an index of left ventricular contraction using MIBI gated SPECT data. The %WT was well correlated with severity scores of both MIBI image (r = -0.70) and BMIPP image (r = -0.72). Thus, ECG-gated dual-isotope SPECT with MIBI and BMIPP was considered to be useful method for assessment of left ventricular contraction as well as myocardial perfusion and fatty acid metabolism.
对25例缺血性心脏病患者进行了99mTc-甲氧基异丁基异腈（MIBI）和123I-β-甲基碘代苯基十五烷酸（BMIPP）的同步双同位素单光子发射计算机断层扫描（SPECT）。在注射MIBI（555 MBq）和BMIPP（148 MBq）后进行心电图门控心肌SPECT检查。MIBI和BMIPP扫描均提供了高质量的心肌图像。然后，使用MIBI门控SPECT数据计算心肌计数增加率（%WT =（舒张末期-收缩末期）/收缩末期×100）作为左心室收缩的指标。%WT与MIBI图像（r = -0.70）和BMIPP图像（r = -0.72）的严重程度评分均具有良好的相关性。因此，MIBI和BMIPP的心电图门控双同位素SPECT被认为是评估左心室收缩以及心肌灌注和脂肪酸代谢的有用方法。
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