Kumita S, Mizumura S, Kijima T, Machida M, Kumazaki T, Tetsuou Y, Sakai S, Kusama Y, Munakata K
Department of Radiology, Nippon Medical School, Tokyo.
Kaku Igaku. 1995 Jun;32(6):547-55.
Simultaneous dual-isotope SPECT with 99mTc-methoxy isobutyl isonitrile (MIBI) and 123I-beta-methyl iodophenyl-pentadecanoic acid (BMIPP) was performed in 25 patients with ischemic heart disease. ECG-gated myocardial SPECT was acquired following the injection of MIBI (555 MBq) and BMIPP (148 MBq). Both MIBI and BMIPP scans provided high-quality myocardial images. Then, myocardial count increase rate (%WT = ES-ED/ED x 100) was calculated as an index of left ventricular contraction using MIBI gated SPECT data. The %WT was well correlated with severity scores of both MIBI image (r = -0.70) and BMIPP image (r = -0.72). Thus, ECG-gated dual-isotope SPECT with MIBI and BMIPP was considered to be useful method for assessment of left ventricular contraction as well as myocardial perfusion and fatty acid metabolism.
对25例缺血性心脏病患者进行了99mTc-甲氧基异丁基异腈（MIBI）和123I-β-甲基碘代苯基十五烷酸（BMIPP）的同步双同位素单光子发射计算机断层扫描（SPECT）。在注射MIBI（555 MBq）和BMIPP（148 MBq）后进行心电图门控心肌SPECT检查。MIBI和BMIPP扫描均提供了高质量的心肌图像。然后，使用MIBI门控SPECT数据计算心肌计数增加率（%WT =（舒张末期-收缩末期）/收缩末期×100）作为左心室收缩的指标。%WT与MIBI图像（r = -0.70）和BMIPP图像（r = -0.72）的严重程度评分均具有良好的相关性。因此，MIBI和BMIPP的心电图门控双同位素SPECT被认为是评估左心室收缩以及心肌灌注和脂肪酸代谢的有用方法。
