Jankowska E, Krutki P, Läckberg Z S, Hammar I
Department of Physiology and Pharmacology, Göteborg University, Sweden.
Neuroscience. 1995 Jul;67(2):489-95. doi: 10.1016/0306-4522(95)00060-v.
Effects of ionophoretic application of serotonin and of one of its agonists were tested on responses of dorsal horn dorsal spinocerebellar tract neurons evoked by electrical stimulation of peripheral nerves. Both drugs depressed monosynaptically evoked actions of group II muscle afferents; they decreased the number and/or increased the latency of spike potentials evoked by these afferents. In contrast, synaptic actions of low-threshold cutaneous afferents (mono- or oligosynaptic) were facilitated in the majority of the neurons, as judged by decrease in the latency of spike potentials evoked by stimulation of a cutaneous nerve and/or an increase in the number of these potentials. It is proposed that facilitatory actions assist in maintaining tonic discharges of dorsal spinocerebellar tract neurons in some movements and that the selective control of group II input is used to correlate activity of spinal and supraspinal neurons. Both actions may be subserved by tight contacts between serotoninergic nerve fibres and dorsal spinocerebellar tract neurons, which have been revealed in a parallel study.
通过离子电泳施加血清素及其一种激动剂，测试其对电刺激外周神经诱发的背角背脊髓小脑束神经元反应的影响。两种药物均单突触抑制II类肌肉传入纤维诱发的动作；它们减少了这些传入纤维诱发的锋电位数量和/或增加了其潜伏期。相反，根据刺激皮神经诱发的锋电位潜伏期缩短和/或这些电位数量增加判断，在大多数神经元中，低阈值皮肤传入纤维（单突触或多突触）的突触作用得到促进。有人提出，促进作用有助于在某些运动中维持背脊髓小脑束神经元的紧张性放电，并且对II类输入的选择性控制用于使脊髓和脊髓上神经元的活动相关联。这两种作用可能都由血清素能神经纤维与背脊髓小脑束神经元之间的紧密接触来实现，这一点已在一项平行研究中得到证实。
