Odano I, Miyashita K, Minoshima S, Nakajima T, Fujita M, Takahashi N, Ikuta F
Department of Radiology, Niigata University School of Medicine, Japan.
Nucl Med Commun. 1995 Jun;16(6):443-6. doi: 10.1097/00006231-199506000-00004.
In the treatment and therapy of patients suffering a stroke, it is very important to predict whether viable neurones, even those of poor function, remain intact in the lesions of the brain. To determine whether viable neurones of low functional activity are represented in in vivo neuroreceptor imaging, we undertook experiments in gerbils with cerebral infarction, in which we examined histological changes and the results of dual-tracer in vivo autoradiography of glucose utilization with 14C-labelled deoxyglucose and benzodiazepine receptor binding with 123I-labelled Ro 16-0154. The unrelated findings of cerebral glucose metabolism and benzodiazepine receptor binding were observed in the primary infarct lesion and in remote areas, including the ipsilateral striatum and thalamus. Our experiments showed that when viable neurones with low functional activity remain intact, normal in vivo binding to benzodiazepine receptors is demonstrated as hypometabolism of glucose utilization. This functional, contrast-enhanced technique with 123I-labelled Ro 16-0154 may have an important role to play in the prediction of neuronal cell viability after recent brain infarction in experimental animals and humans using single photon emission tomography (SPET).
在中风患者的治疗中，预测脑损伤部位是否仍有存活的神经元（即使是功能较差的神经元）完好无损非常重要。为了确定体内神经受体成像中是否显示出功能活动较低的存活神经元，我们用沙土鼠进行了脑梗死实验，在实验中我们检查了组织学变化以及用¹⁴C标记的脱氧葡萄糖进行葡萄糖利用的双示踪剂体内放射自显影结果，以及用¹²³I标记的Ro 16 - 0154进行苯二氮䓬受体结合的结果。在原发性梗死灶以及包括同侧纹状体和丘脑在内的远隔区域观察到了脑葡萄糖代谢和苯二氮䓬受体结合的不相关发现。我们的实验表明，当功能活动较低的存活神经元保持完好时，体内与苯二氮䓬受体的正常结合表现为葡萄糖利用的代谢减退。这种用¹²³I标记的Ro 16 - 0154的功能性、对比增强技术可能在使用单光子发射断层扫描（SPET）预测实验动物和人类近期脑梗死术后神经元细胞活力方面发挥重要作用。
