Sándor J, Ambrus T, Ember I
Pécsi Orvostudományi Egyetem Népegészségtani Intézet.
Orv Hetil. 1995 Aug 27;136(35):1875-83.
The alteration of the p53 gene or protein seems to be the most frequent alteration in the human malignancies. It plays a significant role in the regulation of the physiological cell division. The genetic impairments caused by a series of exogenous or endogenous agents induce the activation of the p53 which results in the G1-S arrest to ensure the opportunity for repair to correct the alteration or in apoptosis when the repair is not able to cope with the mutation. Eventually, the p53 is anticarcinogenic because of its genom guarding function. The investigation of the behavior of this gene and protein is fruitful in solving problems of preventive, diagnostic and therapeutic work.
p53基因或蛋白的改变似乎是人类恶性肿瘤中最常见的改变。它在生理细胞分裂的调节中起着重要作用。一系列外源性或内源性因素引起的基因损伤会诱导p53激活，从而导致G1-S期阻滞，以确保有修复改变的机会，若修复无法应对突变则会导致细胞凋亡。最终，p53因其基因组保护功能而具有抗癌作用。对该基因和蛋白行为的研究在解决预防、诊断和治疗工作的问题方面成果丰硕。
