Hierholzer J, Cordes M, Schelosky L, Richter W, Schrag A, Poewe W, Schulze P E, Semmler W, Eichstädt H, Felix R
Strahlenklinik und Poliklinik, Virchow Klinikum der Humboldt-Universität zu Berlin, FRG.
Nuklearmedizin. 1995 Aug;34(4):141-5.
The goal was to visualize cerebral dopamine-D2 receptors in 6 patients with Parkinson's disease and in 3 healthy controls using iodine-123-Lisuride-SPECT. In addition, we performed receptor-replacement studies using 123I-Lisuride and cold Lisuride as competitive ligands. The highest uptake of 123I-Lisuride was observed in the striatum, a region with known high dopamine receptor density. In two patients premedication with cold Lisuride displaced 123I-Lisuride from the dopamine receptor. 123I-Lisuride is valuable as a radiotracer in cerebral dopamine-D2 receptor scintigraphy. Whether or not it is possible to determine dynamic changes of dopamine receptor density or function by receptor replacement studies needs further evaluation in larger patient populations.
目的是使用碘-123-利苏瑞德单光子发射计算机断层扫描（SPECT）对6例帕金森病患者和3名健康对照者的脑多巴胺D2受体进行可视化。此外，我们使用123I-利苏瑞德和冷利苏瑞德作为竞争性配体进行了受体置换研究。在纹状体中观察到123I-利苏瑞德的摄取最高，纹状体是已知多巴胺受体密度高的区域。在两名患者中，用冷利苏瑞德进行预处理使123I-利苏瑞德从多巴胺受体上 displaced（此处原文似乎有误，推测可能是“displaced，即置换”）。123I-利苏瑞德作为脑多巴胺D2受体闪烁显像中的放射性示踪剂很有价值。是否能够通过受体置换研究确定多巴胺受体密度或功能的动态变化，需要在更大的患者群体中进一步评估。
