Moriarty D D
Department of Psychology, University of San Diego, CA 92110-2492, USA.
Pharmacol Biochem Behav. 1995 Aug;51(4):795-8. doi: 10.1016/0091-3057(95)00036-v.
Tonic immobility (TI) is an innate form of active motor inhibition displayed by many species in response to restraint. It is strongly influenced by manipulations that affect fear, and is thought to be the last in a series of responses to attack by a predator. The suggestion that GABA systems may be involved in TI was investigated by assessing the effects of the alpha-GABAA inverse agonist beta-CCM (beta-carboline-3-carboxylic acid-N-methylamide), which is thought to have anxiogenic properties, on the immobility response and open field behavior in chickens (Gallus gallus). Birds given beta-CCM displayed longer durations of TI than those given control injections. Although there was a tendency towards increased susceptibility in the groups given the drug, it was not significant. In the open field test, the drug reduced activity and vocalization relative to control levels. The results are discussed in terms of the involvement of GABA systems in TI and related behaviors, and the suggestion that alpha-GABAA inverse agonists are anxiogenic agents.
紧张性不动（TI）是许多物种在受到束缚时表现出的一种先天性主动运动抑制形式。它受到影响恐惧的操作的强烈影响，并且被认为是对捕食者攻击的一系列反应中的最后一种。通过评估α-GABAA反向激动剂β-CCM（β-咔啉-3-羧酸-N-甲基酰胺）对鸡（原鸡）的不动反应和旷场行为的影响，研究了GABA系统可能参与TI的这一假设。β-CCM处理组的鸡表现出比给予对照注射组更长时间的紧张性不动。虽然给药组有易感性增加的趋势，但并不显著。在旷场试验中，与对照水平相比，该药物降低了活动和发声。本文根据GABA系统在紧张性不动及相关行为中的作用，以及α-GABAA反向激动剂是致焦虑剂的观点对结果进行了讨论。
