Derivan A T
Wyeth-Ayerst Laboratories, Radnor, PA 19087, USA.
Psychopharmacol Bull. 1995;31(1):23-8.
Published reports of antidepressants in clinical trials were reviewed by conducting a literature search focusing on the time period between 1969 and 1994; 240 English-language articles were identified. In these, considerable variation was noted in how study data were evaluated. A few particular points of view concerning antidepressant speed of onset were abstracted. These demonstrate that both antidepressant and placebo treatment of depressed patients are associated with measurable clinical activity during the first weeks of therapy. Methods currently exist to determine speed of antidepressant onset. However, at least one proposed method (Quitkin's pattern analysis) has not yet identified any fast-acting antidepressants. Further work is needed to refine the methods of studying antidepressant onset of action. It is most important that antidepressant drugs with early, clinically relevant onset of activity be identified.
通过进行文献检索，对1969年至1994年期间发表的关于抗抑郁药临床试验的报告进行了回顾；共识别出240篇英文文章。在这些文章中，研究数据的评估方式存在很大差异。提取了一些关于抗抑郁药起效速度的特定观点。这些观点表明，对抑郁症患者使用抗抑郁药和安慰剂治疗在治疗的最初几周都与可测量的临床活性相关。目前存在确定抗抑郁药起效速度的方法。然而，至少有一种提议的方法（奎特金的模式分析）尚未识别出任何速效抗抑郁药。需要进一步开展工作来完善研究抗抑郁药起效作用的方法。识别出具有早期、临床相关活性起效的抗抑郁药最为重要。
