Peetermans W E, De Man F
Maladies Infectieuses Afd. Algemeen Inwendige Geneeskunde.
Rev Belge Med Dent (1984). 1995;50(1):34-45.
Infective endocarditis causes substantial morbidity and mortality despite adequate antimicrobial, medical and surgical treatment. The rationale for antibiotic prophylaxis against endocarditis is derived from the etiology and pathogenesis of the disease. Endocarditis usually follows bacteremia with certain endocarditis-prone bacteria in a patient with a predisposing heart condition. Protection by antibiotic prophylaxis is estimated to reach only 50% for a lot of reasons (transient bacteremia without dental or surgical intervention, predisposing heart disease not diagnosed previously, etc). Most authorities in the field of infective endocarditis strongly advocate the use of antibiotic prophylaxis for patients at risk. Clear guidelines are published by various highly qualified scientific committees. Recent schemes allow orally administered antibiotic prophylaxis because of a better doctor and patient compliance.
尽管有充分的抗菌、内科及外科治疗,感染性心内膜炎仍会导致严重的发病和死亡。针对心内膜炎进行抗生素预防的理论依据源于该疾病的病因和发病机制。心内膜炎通常在有易患心脏病的患者中,由某些易引发心内膜炎的细菌导致菌血症后发生。由于多种原因(无牙科或外科干预时的短暂菌血症、先前未诊断出的易患心脏病等),抗生素预防的保护作用估计仅达到50%。感染性心内膜炎领域的大多数权威人士强烈主张对有风险的患者使用抗生素预防。各种高素质科学委员会发布了明确的指南。由于医生和患者的依从性更好,近期的方案允许口服抗生素预防。