Smadja D, Bellance R, Cabre P, Kerjean J, Lezin A, Vernant J C
Service de Neurologie, CHU, Fort-de-France.
Rev Neurol (Paris). 1995 Mar;151(3):190-5.
The main neurological manifestation due to Human T-Cell Lymphotropic Virus type (HTLV1) infection is a chronic spastic paraparesis called HTLV1-associated paraparesis (HAP). Since 1985, we observed in Martinique (French West Indies) 276 cases of HAP. Among them, 70 patients fulfilled clinical, electrophysiological or histological criteria of associated peripheral nervous system involvement (42/70), myositis (8/70), or both (20/70). Muscle biopsy revealed neurogenic atrophy of muscle fibers or myositic changes in 41/70. Neuromuscular involvement was only mild in 19/70. On the other hand, 25 patients presented with a syndrome mimicking amyotrophic lateral sclerosis, and 7 other patients with features of polymyositis. This study shows that neurological manifestations associated to HTLV1 infection may be more complex than the well-known chronic spastic paraparesis, since 25.4% of the HAP Martinican patients exhibit neuropathic or myositic features.
人类嗜T淋巴细胞病毒1型（HTLV1）感染所致的主要神经表现是一种称为HTLV1相关性轻截瘫（HAP）的慢性痉挛性轻截瘫。自1985年以来，我们在马提尼克岛（法属西印度群岛）观察到276例HAP病例。其中，70例患者符合相关外周神经系统受累（42/70）、肌炎（8/70）或两者皆有（20/70）的临床、电生理或组织学标准。肌肉活检显示70例中有41例存在肌纤维神经源性萎缩或肌炎改变。70例中有19例神经肌肉受累仅为轻度。另一方面，25例患者表现出类似肌萎缩侧索硬化的综合征，另有7例患者具有多发性肌炎的特征。这项研究表明，与HTLV1感染相关的神经表现可能比众所周知的慢性痉挛性轻截瘫更为复杂，因为25.4%的马提尼克岛HAP患者表现出神经病变或肌炎特征。
