Abe M, Nishimura Y, Shibamoto Y
Department of Radiology, Faculty of Medicine, Kyoto University, Japan.
World J Surg. 1995 Jul-Aug;19(4):544-7. doi: 10.1007/BF00294720.
From among 115 patients who were treated by intraoperative radiation therapy (IORT), 94 patients were classified according to the histologic findings. The control 127 patients who were treated by operation alone during the same period were also histologically classified, and survivals were compared between the two groups. No difference in the survivals of patients with stage I was observed for the two groups. On the other hand, the survivals of patients with stages II through IV who were treated by IORT increased by nearly 10% to 20% at 5 years. A comparative study was also performed on the survivals between patients treated by IORT and those treated by operation alone according to the presence or absence of the serosal invasion and the grade of the lymph node metastasis. The number of patients treated by IORT in whom the serosal invasion and the lymph node metastasis were histologically examined was 57. The 171 control patients who underwent operation alone were examined histologically in the same fashion, and survivals for the two groups were compared. IORT did not afford any benefit if the lymph node metastasis was limited within n1 group or serosal invasion was not found. On the other hand, the 5-year survival rates for patients who were treated by IORT increased by nearly 10% when the serosal invasion was observed and by nearly 18% when n2 and n3 lymph node metastases were found.
在接受术中放射治疗(IORT)的115例患者中,94例患者根据组织学检查结果进行了分类。同时,对同期仅接受手术治疗的127例对照患者也进行了组织学分类,并比较了两组患者的生存率。两组I期患者的生存率未观察到差异。另一方面,接受IORT治疗的II至IV期患者在5年时的生存率提高了近10%至20%。还根据浆膜侵犯和淋巴结转移的有无,对接受IORT治疗的患者与仅接受手术治疗的患者的生存率进行了比较研究。接受IORT治疗且经组织学检查有浆膜侵犯和淋巴结转移的患者有57例。以同样方式对171例仅接受手术治疗的对照患者进行了组织学检查,并比较了两组的生存率。如果淋巴结转移局限于n1组或未发现浆膜侵犯,IORT没有任何益处。另一方面,当观察到浆膜侵犯时,接受IORT治疗的患者5年生存率提高了近10%,当发现n2和n3淋巴结转移时,5年生存率提高了近18%。