Rowland R T, Cleveland J C, Meng X, Harken A H, Brown J M
Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA.
Ann Thorac Surg. 1995 Sep;60(3):721-8. doi: 10.1016/0003-4975(95)00476-2.
Gene therapy is the introduction of new genetic material into somatic cells to synthesize missing or defective proteins. Efficient methods for the introduction of genetic material into cells are available, both in vitro and in vivo. These strategies involve chemical, physical, and viral-mediated mechanisms of gene transfer. Application of these gene transfer techniques has led to the development of potential gene-based treatment strategies that could combat vascular and myocardial disease. Gene therapy in the treatment of cardiovascular disease promises to alter atherosclerotic risk factors, prevent vascular thrombotic disease, retard progression of disease in the peripheral vasculature, provide drug delivery systems, and prevent myocardial infarction in patients with coronary artery disease. This exciting technology will eventually become the ultimate intervention in the treatment of cardiovascular disease.
基因治疗是将新的遗传物质导入体细胞以合成缺失或有缺陷的蛋白质。无论是在体外还是体内，都有将遗传物质导入细胞的有效方法。这些策略涉及化学、物理和病毒介导的基因转移机制。这些基因转移技术的应用已促成了可能对抗血管和心肌疾病的潜在基因治疗策略的发展。基因治疗在心血管疾病治疗中有望改变动脉粥样硬化风险因素、预防血管血栓形成疾病、延缓外周血管疾病进展、提供药物递送系统并预防冠状动脉疾病患者的心肌梗死。这项令人兴奋的技术最终将成为心血管疾病治疗的终极干预手段。
