Malpas T J, Darlow B A, Lennox R, Horwood L J
Department of Paediatrics, Christchurch Hospital, New Zealand.
Aust N Z J Obstet Gynaecol. 1995 May;35(2):175-7. doi: 10.1111/j.1479-828x.1995.tb01863.x.
The aim of this study was to assess the influence of maternal methadone dosage on the severity of neonatal withdrawal. The charts of 67 drug-abusing mothers and their 70 infants were examined to determine documented patterns of drug usage and the severity of neonatal withdrawal. Of these, 40 women were on a methadone programme. There was a strong relationship between maternal methadone dose at delivery and severity of neonatal withdrawal as assessed by the Neonatal Abstinence Score, length of stay and duration of treatment. Children whose mothers received methadone had mean peak symptom scores greater than 10 whereas the group receiving no methadone had mean scores of less than 4 (p < 0.001). These effects tended to increase with increasing doses of methadone. Length of stay and duration of neonatal treatment showed highly statistically significant increases (p < 0.001) with increasing methadone dose. Maternal methadone dose appears to be strongly related to the severity of neonatal withdrawal.
本研究的目的是评估母亲美沙酮剂量对新生儿戒断严重程度的影响。检查了67名滥用药物母亲及其70名婴儿的病历，以确定记录的用药模式和新生儿戒断的严重程度。其中，40名女性参加了美沙酮治疗项目。根据新生儿戒断评分、住院时间和治疗持续时间评估，分娩时母亲美沙酮剂量与新生儿戒断严重程度之间存在密切关系。母亲接受美沙酮治疗的儿童平均峰值症状评分大于10，而未接受美沙酮治疗的组平均评分小于4（p<0.001）。这些影响倾向于随着美沙酮剂量的增加而增加。随着美沙酮剂量的增加，住院时间和新生儿治疗持续时间显示出高度统计学意义的增加（p<0.001）。母亲美沙酮剂量似乎与新生儿戒断严重程度密切相关。
