Simske S J, Luttges M W
Department of Aerospace Engineering Sciences, University of Colorado, Boulder 80309, USA.
Bioelectromagnetics. 1995;16(3):152-9. doi: 10.1002/bem.2250160303.
Whole-body fields were tested for their efficacy in preventing the osteopenia caused by tail suspension in mice. The fields had fundamental frequencies corresponding to the upper range of predicted endogenous impact-generated frequencies (0.25-2.0 kHz) in the long bones. Three distinct whole-body EMFs were applied for 2 weeks on growing mice. Structural, geometric, and material properties of the femora, tibiae, and humeri of suspended mice were altered compared to controls. Comparison of suspended mice and mice subjected to caloric restriction indicates that the changes in caloric intake do not explain either the suspension or the field-induced effects. In agreement with past studies, rather, unloading appears to cause the suspension effects and to be addressed by the EMFs. The EMF effects on bone properties were apparently frequency dependent, with the lower two fundamental frequencies (260 and 910 Hz) altering, albeit slightly, the suspension-induced bone effects. The fields are not apparently optimized for frequency, etc., with respect to therapeutic potential; however, suspension provides a model system for further study of the in vivo effects of EMFs.
测试了全身电磁场在预防小鼠尾部悬吊引起的骨质减少方面的功效。这些电磁场的基频对应于长骨中预测的内源性冲击产生频率的上限（0.25 - 2.0千赫兹）。对生长中的小鼠施加三种不同的全身电磁场，持续2周。与对照组相比，悬吊小鼠的股骨、胫骨和肱骨的结构、几何形状和材料特性发生了改变。悬吊小鼠与热量限制小鼠的比较表明，热量摄入的变化并不能解释悬吊或电磁场诱导的效应。相反，与过去的研究一致，卸载似乎会导致悬吊效应，而电磁场可以解决这一问题。电磁场对骨骼特性的影响显然与频率有关，较低的两个基频（260和910赫兹）虽然轻微，但改变了悬吊诱导的骨骼效应。就治疗潜力而言，这些电磁场在频率等方面显然没有得到优化；然而，悬吊为进一步研究电磁场的体内效应提供了一个模型系统。
