转化生长因子-β1与前列腺癌的关联：一项免疫组织化学研究。

Association of transforming growth factor-beta 1 with prostate cancer: an immunohistochemical study.

作者信息

Truong L D, Kadmon D, McCune B K, Flanders K C, Scardino P T, Thompson T C

机构信息

Department of Pathology, Methodist Hospital, Houston, TX.

出版信息

Hum Pathol. 1993 Jan;24(1):4-9. doi: 10.1016/0046-8177(93)90055-l.

DOI:10.1016/0046-8177(93)90055-l

PMID:7678092

Abstract

Prostate tissue samples from patients with prostatic carcinoma (PC) and/or benign prostatic hyperplasia (BPH) were examined for expression of transforming growth factor-beta 1 (TGF-beta 1) using an immunohistochemical technique. Tissues were stained with CC and LC antisera, which react with extracellular and intracellular TGF-beta 1, respectively. All PC and BPH tissues showed positive extracellular staining; however, CC-immunoreactive material was significantly more extensive in PC compared with BPH, the average positively staining areas being 59% and 26%, respectively. This differential staining pattern was evident in cases in which areas of PC were located adjacent to areas of BPH. LC staining was identified exclusively intracellularly involving both stromal and epithelial cells in cases of PC as well as BPH. However, while stromal cell staining was more pronounced in BPH, epithelial cell staining tended to be more extensive and more intense in PC. The findings suggest that TGF-beta 1 may be biologically important in the development of PC and BPH.

摘要

采用免疫组织化学技术检测前列腺癌（PC）和/或良性前列腺增生（BPH）患者的前列腺组织样本中转化生长因子β1（TGF-β1）的表达。组织分别用CC和LC抗血清染色，它们分别与细胞外和细胞内的TGF-β1反应。所有PC和BPH组织均显示细胞外染色阳性；然而，与BPH相比，PC中CC免疫反应性物质明显更广泛，平均阳性染色面积分别为59%和26%。在PC区域与BPH区域相邻的病例中，这种差异染色模式很明显。LC染色仅在细胞内发现，在PC和BPH病例中均涉及基质细胞和上皮细胞。然而，虽然BPH中基质细胞染色更明显，但PC中上皮细胞染色往往更广泛、更强烈。这些发现表明，TGF-β1可能在PC和BPH的发生发展中具有重要生物学意义。