al-Shabanah O A
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mutat Res. 1993 Feb;301(2):107-11. doi: 10.1016/0165-7992(93)90032-q.
Swiss albino male mice, 6-8 weeks old, were treated i.p. with different doses of desferrioxamine dissolved in water for 7 days. Some of the mice in each group were injected i.p. with adriamycin (15 mg/kg) and killed after 30 or 24, 48 and 72 h. The femoral cells of mice in different groups were collected and studied. Desferrioxamine treatment failed to affect the incidence of micronuclei at doses of 125-250 mg/kg/day. Pretreatment with desferrioxamine was found to provide significant protection against adriamycin-induced micronuclei without interfering with its cytotoxic potential.
6至8周龄的瑞士白化雄性小鼠经腹腔注射不同剂量溶于水的去铁胺，持续7天。每组中的一些小鼠经腹腔注射阿霉素（15毫克/千克），并在30小时或24、48和72小时后处死。收集并研究不同组小鼠的股骨细胞。去铁胺治疗在剂量为125至250毫克/千克/天时未能影响微核发生率。发现去铁胺预处理可显著保护小鼠免受阿霉素诱导的微核影响，且不干扰其细胞毒性潜力。
