• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

N-nitrosodimethylamine, N-nitrosodiethylamine, and N-nitrosomorpholine fail to generate 8-hydroxy-2'-deoxyguanosine in liver DNA of male F344 rats.

作者信息

Dahlhaus M, Appel K E

机构信息

Max von Pettenkofer Institute, Federal Health Office, Berlin, Germany.

出版信息

Mutat Res. 1993 Feb;285(2):295-302. doi: 10.1016/0027-5107(93)90118-y.

DOI:10.1016/0027-5107(93)90118-y
PMID:7678903
Abstract

The possible oxidative effects of the hepatocarcinogens 2-nitropropane (2-NP), N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA) and N-nitrosomorpholine (NMOR) on nuclear DNA were studied in vivo in male F344 rats. 2-NP and the N-nitrosamines were administered intraperitoneally. In addition, NDEA was given by gavage. DNA was isolated from rat liver and hydrolysed enzymatically. Oxidative DNA damage was determined by measuring 8-hydroxy-2'-deoxyguanosine (8-OH-dG) in a mixture of 2'-deoxyribonucleosides by electrochemical detection. This method allows a detection limit of about 0.1 residue 8-OH-dG per 10(5) 2'-deoxyguanosine (dG). 2-NP drastically increased the content of 8-OH-dG in rat liver by a factor of ca. 12. No elevation above control values could be proved after having dosed the rats with N-nitrosamines.

摘要

相似文献

1
N-nitrosodimethylamine, N-nitrosodiethylamine, and N-nitrosomorpholine fail to generate 8-hydroxy-2'-deoxyguanosine in liver DNA of male F344 rats.
Mutat Res. 1993 Feb;285(2):295-302. doi: 10.1016/0027-5107(93)90118-y.
2
DNA adducts from N-nitrosodiethanolamine and related beta-oxidized nitrosamines in vivo: (32)P-postlabeling methods for glyoxal- and O(6)-hydroxyethyldeoxyguanosine adducts.体内 N-亚硝基二乙醇胺及相关β-氧化亚硝胺产生的 DNA 加合物：乙二醛和 O(6)-羟基乙基脱氧鸟苷加合物的(32)P 后标记法
Chem Res Toxicol. 2002 Apr;15(4):470-82. doi: 10.1021/tx0101393.
3
Increased 8-oxodeoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with the tobacco-specific nitrosamine 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone.用烟草特异性亚硝胺4-（甲基亚硝胺）-1-（3-吡啶基）-1-丁酮处理的A/J小鼠和F344大鼠肺DNA中8-氧代脱氧鸟苷水平升高。
Carcinogenesis. 1992 Jul;13(7):1269-72. doi: 10.1093/carcin/13.7.1269.
4
Elevated 8-hydroxy-2'-deoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and inhibition by dietary 1,4-phenylenebis(methylene)selenocyanate.用4-（甲基亚硝胺基）-1-（3-吡啶基）-1-丁酮处理的A/J小鼠和F344大鼠肺DNA中8-羟基-2'-脱氧鸟苷水平升高以及膳食亚硒酸1,4-苯撑双（亚甲基）酯的抑制作用
Carcinogenesis. 1998 Oct;19(10):1783-8. doi: 10.1093/carcin/19.10.1783.
5
DNA single-strand breaks and toxicity induced by 4-(methyl-nitrosamino)-1-(3- pyridyl)-1-butanone or N-nitrosodimethylamine in hamster and rat liver.4-（甲基亚硝基氨基）-1-（3-吡啶基）-1-丁酮或N-亚硝基二甲胺在仓鼠和大鼠肝脏中诱导的DNA单链断裂及毒性
Carcinogenesis. 1994 Feb;15(2):389-94. doi: 10.1093/carcin/15.2.389.
6
Chronic nitrosamine ingestion in 1040 rodents: the effect of the choice of nitrosamine, the species studied, and the age of starting exposure.1040只啮齿动物长期摄入亚硝胺：亚硝胺选择、所研究物种及开始接触时年龄的影响
Cancer Res. 1991 Dec 1;51(23 Pt 2):6470-91.
7
Clearance of N-nitrosodimethylamine and N-nitrosodiethylamine by the perfused rat liver. Relationship to the Km and Vmax for nitrosamine metabolism.灌注大鼠肝脏对N-亚硝基二甲胺和N-亚硝基二乙胺的清除。与亚硝胺代谢的米氏常数（Km）和最大反应速度（Vmax）的关系。
Biochem Pharmacol. 1993 Mar 9;45(5):983-9. doi: 10.1016/0006-2952(93)90240-w.
8
Mutation and formation of methyl- and hydroxylguanine adducts in DNA caused by N-nitrosodimethylamine and N-nitrosodiethylamine with UVA irradiation.
Carcinogenesis. 1997 Dec;18(12):2429-33. doi: 10.1093/carcin/18.12.2429.
9
The effects of ascorbic acid deficiency and excess on the metabolism and toxicity of N-nitrosodimethylamine and N-nitrosodiethylamine in the guinea pig.抗坏血酸缺乏和过量对豚鼠体内N-亚硝基二甲胺和N-亚硝基二乙胺代谢及毒性的影响。
Carcinogenesis. 1984 Apr;5(4):533-6. doi: 10.1093/carcin/5.4.533.
10
Evaluation of the protective effect of ascorbic acid on nitrite- and nitrosamine-induced cytotoxicity and genotoxicity in human hepatoma line.评价抗坏血酸对亚硝酸盐和亚硝胺诱导的人肝癌细胞系细胞毒性和遗传毒性的保护作用。
Toxicol Mech Methods. 2010 Feb;20(2):45-52. doi: 10.3109/15376510903583711.

引用本文的文献

1
A newly identified small tRNA fragment reveals the regulation of different wool types and oxidative stress in lambs.一种新鉴定的小 tRNA 片段揭示了羔羊不同羊毛类型和氧化应激的调控。
Sci Rep. 2023 Jun 23;13(1):10213. doi: 10.1038/s41598-023-36895-7.
2
Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression.钒在化学性肝癌发生啮齿动物模型中的化学预防作用：氧化DNA损伤、能量色散X射线荧光谱及金属硫蛋白表达方面的体现
J Biol Inorg Chem. 2006 Oct;11(7):855-66. doi: 10.1007/s00775-006-0128-3. Epub 2006 Jul 8.
3
Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor kappaB expression and enhanced antiapoptosis-related proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma.
幽门螺杆菌感染的非贲门胃腺癌中氧化DNA损伤增加、诱导型一氧化氮合酶、核因子κB表达及抗凋亡相关蛋白增强。
World J Gastroenterol. 2004 Aug 1;10(15):2232-40. doi: 10.3748/wjg.v10.i15.2232.