Gilbert-Barness E, Kenison K, Carver J
Department of Pathology, University of Wisconsin Medical School, Madison.
Arch Pathol Lab Med. 1993 Feb;117(2):177-9.
Chronic hypoxemia has been suggested as an unrecognized condition that may result in sudden infant death syndrome. Fetal hemoglobin has been shown to be increased in infants suffering from chronic hypoxemia. We examined fetal hemoglobin levels in 54 cases of sudden infant death syndrome, 17 infants dying of other causes, and 22 live, healthy control infants. Fetal hemoglobin in infants with sudden infant death syndrome was found to be elevated when compared with our control infants as well as when compared with literature-based normal values. These findings indicate that fetal hemoglobin measurements may be a valuable aid in identifying cases of sudden infant death syndrome at autopsy and supports the hypothesis that this group of victims of sudden infant death syndrome are not normal before death but have an underlying condition resulting in chronic hypoxemia.
慢性低氧血症被认为是一种未被认识的状况，可能导致婴儿猝死综合征。已有研究表明，患有慢性低氧血症的婴儿体内胎儿血红蛋白水平会升高。我们检测了54例婴儿猝死综合征患儿、17例死于其他原因的婴儿以及22例健康存活婴儿的胎儿血红蛋白水平。结果发现，与我们的对照婴儿以及基于文献的正常数值相比，婴儿猝死综合征患儿的胎儿血红蛋白水平均有所升高。这些发现表明，检测胎儿血红蛋白水平可能有助于在尸检时识别婴儿猝死综合征病例，并支持这样一种假说，即这组婴儿猝死综合征受害者在死亡前并非正常状态，而是存在导致慢性低氧血症的潜在病症。
