表柔比星与5-氟尿嘧啶对比顺铂用于晚期复发性涎腺恶性肿瘤姑息治疗的随机II期试验
A randomised phase II trial of epirubicin and 5-fluorouracil versus cisplatinum in the palliation of advanced and recurrent malignant tumour of the salivary glands.
作者信息
Jones A S, Phillips D E, Cook J A, Helliwell T R
机构信息
Department of Otorhinolaryngology, University of Liverpool, UK.
出版信息
Br J Cancer. 1993 Jan;67(1):112-4. doi: 10.1038/bjc.1993.19.
Abstract
Sixteen patients with advanced and recurrent malignant salivary gland tumours were admitted to a randomised trial and the response assessed. Seven patients received Epirubicin/5-Fluorouracil and none of these patients responded. Nine patients received Cisplatinum and only one patient had a partial response. The trial suggests that chemotherapy has no place in the treatment of advanced salivary gland malignant tumours.
摘要
16例晚期复发性涎腺恶性肿瘤患者被纳入一项随机试验并评估疗效。7例患者接受表柔比星/5-氟尿嘧啶治疗，这些患者均无反应。9例患者接受顺铂治疗，只有1例患者有部分反应。该试验表明化疗在晚期涎腺恶性肿瘤的治疗中没有地位。
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本文引用的文献
1
INFUSION OF 5-FLUOROURACIL IN CYLINDROMA TREATMENT.5-氟尿嘧啶在圆柱瘤治疗中的输注
Arch Otolaryngol. 1964 Jun;79:625-7. doi: 10.1001/archotol.1964.00750030638012.
2
The determinatio of the number of patients required in a preliminary and a follow-up trial of a new chemotherapeutic agent.一种新型化疗药物的初步试验和后续试验所需患者数量的确定。
J Chronic Dis. 1961 Apr;13:346-53. doi: 10.1016/0021-9681(61)90060-1.
3
Reporting results of cancer treatment.癌症治疗结果报告。
Cancer. 1981 Jan 1;47(1):207-14. doi: 10.1002/1097-0142(19810101)47:1<207::aid-cncr2820470134>3.0.co;2-6.
4
Adriamycin/cis-platinum/cyclophosphamide combination chemotherapy for advanced carcinoma of the parotid gland.阿霉素/顺铂/环磷酰胺联合化疗治疗晚期腮腺癌。
Cancer. 1981 Feb 15;47(4):645-8. doi: 10.1002/1097-0142(19810215)47:4<645::aid-cncr2820470404>3.0.co;2-a.
5
Cyclophosphamide, adriamycin, and cis-diamminedichloroplatinum (II) in the treatment of advanced nonsquamous cell head and neck cancer.
Cancer. 1983 Dec 1;52(11):2007-10. doi: 10.1002/1097-0142(19831201)52:11<2007::aid-cncr2820521106>3.0.co;2-t.
6
Adenoid cystic carcinoma of the salivary gland. Sustained complete response to chemotherapy.
Cancer. 1983 Feb 15;51(4):589-90. doi: 10.1002/1097-0142(19830215)51:4<589::aid-cncr2820510405>3.0.co;2-q.
7
Complete response of a metastatic adenoid cystic carcinoma of the parotid gland to chemotherapy.
Cancer. 1981 Jun 1;47(11):2543-8. doi: 10.1002/1097-0142(19810601)47:11<2543::aid-cncr2820471103>3.0.co;2-4.
8
Chemotherapy for adenocystic carcinoma.腺囊性癌的化疗
Cancer. 1980 Aug 1;46(3):452-4. doi: 10.1002/1097-0142(19800801)46:3<452::aid-cncr2820460305>3.0.co;2-z.
9
Carcinoma of major salivary glands.大唾液腺癌
Cancer. 1980 Feb 15;45(4):693-7. doi: 10.1002/1097-0142(19800215)45:4<693::aid-cncr2820450413>3.0.co;2-q.
10
Effects of chlorambucil (NSC-3088) in 374 patients with advanced cancer. Eastern Clinical Drug Evualuation Program.
Cancer Chemother Rep. 1968 Oct;52(6):661-6.
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