Grencis R K, Else K J, Huntley J F, Nishikawa S I
Department of Cell and Structural Biology, University of Manchester, UK.
Parasite Immunol. 1993 Jan;15(1):55-9. doi: 10.1111/j.1365-3024.1993.tb00572.x.
The role of stem cell factor (SCF) in the generation of intestinal mast cell hyperplasia and host protective immunity following helminth infection was investigated using the Trichinella spiralis/mouse model. In vivo administration of a monoclonal antibody specific for the receptor for SCF (c-kit) was found to completely prevent the generation of intestinal mastocytosis normally observed following T. spiralis infection. This was reflected by markedly reduced intestinal mast cell protease (IMCP) levels in both tissue and serum. Moreover, animals treated with anti-c-kit antibody failed to show any evidence of worm expulsion from the gut. The data demonstrate for the first time, a critical role for the SCF in the generation of mucosal mastocytosis and host protective immunity following an intestinal helminth infection.
利用旋毛虫/小鼠模型研究了干细胞因子（SCF）在蠕虫感染后肠道肥大细胞增生和宿主保护性免疫产生中的作用。发现体内给予针对SCF受体（c-kit）的单克隆抗体可完全阻止旋毛虫感染后通常观察到的肠道肥大细胞增多症的产生。这在组织和血清中肠道肥大细胞蛋白酶（IMCP）水平显著降低中得到体现。此外，用抗c-kit抗体处理的动物没有显示出任何肠道蠕虫排出的迹象。这些数据首次证明了SCF在肠道蠕虫感染后黏膜肥大细胞增多症和宿主保护性免疫产生中的关键作用。
