肾移植后FK 506/泼尼松与FK 506/硫唑嘌呤/泼尼松对比的随机试验：初步报告
Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report.
作者信息
Shapiro R, Jordan M L, Scantlebury V P, Fung J J, Jensen C, Vivas C, McCauley J, Irish W D, Mitchell S, Demetris A J
机构信息
Department of Surgery, University of Pittsburgh Health Science Center, Pennsylvania.
出版信息
Transplant Proc. 1993 Feb;25(1 Pt 1):669-72.
Abstract
FK 506 was used as a primary immunosuppressive agent in 125 cases of renal transplantation in a randomized trial comparing FK 506/prednisone with FK 506/azathioprine/prednisone. With a mean follow-up of 5.5 +/- 2.5 months, there has been a 6-month actuarial patient survival of 99% and graft survival of 88%. There is no difference thus far between the two-drug and three-drug groups, although there may be less rejection and diabetes in the three-drug group. These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.
摘要
在一项将FK 506/泼尼松与FK 506/硫唑嘌呤/泼尼松进行对比的随机试验中，FK 506被用作125例肾移植患者的主要免疫抑制剂。平均随访时间为5.5±2.5个月，6个月时患者实际生存率为99%，移植物生存率为88%。到目前为止，两药组和三药组之间没有差异，尽管三药组的排斥反应和糖尿病可能较少。这些结果表明，FK 506在肾移植中是一种有用的免疫抑制剂。
相似文献
1
Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report.肾移植后FK 506/泼尼松与FK 506/硫唑嘌呤/泼尼松对比的随机试验：初步报告
Transplant Proc. 1993 Feb;25(1 Pt 1):669-72.
2
3
Role of protocol biopsies in the treatment of refractory renal allograft rejection with FK 506.协议活检在使用FK 506治疗难治性肾移植排斥反应中的作用。
Transplant Proc. 1996 Apr;28(2):998-9.
4
A prospective, randomized trial of tacrolimus/prednisone vs tacrolimus/prednisone/mycophenolate mofetil in renal transplantation: 1-year actuarial follow-up.他克莫司/泼尼松与他克莫司/泼尼松/霉酚酸酯用于肾移植的前瞻性随机试验：1年精算随访
Transplant Proc. 1999 Feb-Mar;31(1-2):1134. doi: 10.1016/s0041-1345(98)01935-6.
5
A prospective, randomized trial of FK-506 in renal transplantation--a comparison between double- and triple-drug therapy.FK-506在肾移植中的前瞻性随机试验——双药疗法与三药疗法的比较。
Clin Transplant. 1994 Dec;8(6):508-15.
6
Treatment of acute renal transplant rejection with FK 506 in patients on cyclosporine after failure of standard antirejection therapy.
Transplant Proc. 1996 Dec;28(6):3165.
7
Clinical study of FK 506 in renal transplant recipients.
Transplant Proc. 2000 Nov;32(7):1704. doi: 10.1016/s0041-1345(00)01407-x.
8
FK 506 in the management of nephrotic syndrome after renal transplantation.FK506在肾移植后肾病综合征管理中的应用
Transplant Proc. 1993 Feb;25(1 Pt 2):1351-4.
9
Clinical experience with Prograf (tacrolimus, FK 506) in Chinese patients after renal transplantation.
Transplant Proc. 2000 Nov;32(7):1709-10. doi: 10.1016/s0041-1345(00)01405-6.
10
A randomized trial with steroids and antithymocyte globulins comparing cyclosporine/azathioprine versus tacrolimus/mycophenolate mofetil (CATM2) in renal transplantation.一项关于激素和抗胸腺细胞球蛋白的随机试验，比较环孢素/硫唑嘌呤与他克莫司/霉酚酸酯（CATM2）在肾移植中的疗效。
Transplantation. 2012 Feb 27;93(4):437-43. doi: 10.1097/TP.0b013e31824215b7.
引用本文的文献
1
Steroid avoidance or withdrawal for kidney transplant recipients.肾移植受者的类固醇避免或停用
Cochrane Database Syst Rev. 2016 Aug 22;2016(8):CD005632. doi: 10.1002/14651858.CD005632.pub3.
2
Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients.基于模型的体外毒性数据情境化定量预测患者体内药物反应。
Arch Toxicol. 2017 Feb;91(2):865-883. doi: 10.1007/s00204-016-1723-x. Epub 2016 May 9.
3
A prospective, randomized trial to compare tacrolimus and prednisone with and without mycophenolate mofetil in patients undergoing renal transplantation: first report.一项比较他克莫司和泼尼松联合或不联合霉酚酸酯用于肾移植患者的前瞻性随机试验：首次报告。
J Urol. 1998 Dec;160(6 Pt 1):1982-5; discussion 1985-6. doi: 10.1097/00005392-199812010-00009.
4
HLA and cross-reactive antigen group matching for cadaver kidney allocation.用于尸体肾分配的人类白细胞抗原及交叉反应抗原组匹配
Transplantation. 1997 Oct 15;64(7):983-91. doi: 10.1097/00007890-199710150-00009.
5
6
Renal transplantation under FK 506 in African-Americans: early experience.非裔美国人在使用FK506情况下的肾移植：早期经验
Transplant Proc. 1993 Aug;25(4):2468-9.
7
Renal transplantation at the University of Pittsburgh: the impact of FK506.匹兹堡大学的肾移植：FK506的影响。
Clin Transpl. 1994:229-36.
8
A risk-benefit assessment of tacrolimus in transplantation.他克莫司在移植中的风险效益评估。
Drug Saf. 1995 May;12(5):348-57. doi: 10.2165/00002018-199512050-00006.
9
A prospective randomized trial of FK506-based immunosuppression after renal transplantation.肾移植后基于FK506免疫抑制的前瞻性随机试验。
Transplantation. 1995 Feb 27;59(4):485-90. doi: 10.1097/00007890-199559040-00007.
10
A prospective, randomized trial of FK-506 in renal transplantation--a comparison between double- and triple-drug therapy.FK-506在肾移植中的前瞻性随机试验——双药疗法与三药疗法的比较。
Clin Transplant. 1994 Dec;8(6):508-15.
本文引用的文献
1
FK 506 in clinical kidney transplantation.FK506在临床肾移植中的应用
Transplant Proc. 1991 Dec;23(6):3065-7.
2
Kidney transplantation under FK 506 immunosuppression.在FK506免疫抑制下进行肾移植。
Transplant Proc. 1991 Feb;23(1 Pt 2):920-3.
3
Kidney transplantation under FK 506.在使用FK506的情况下进行肾脏移植。
JAMA. 1990 Jul 4;264(1):63-7.
Zotero 插件