Kuban D A, el-Mahdi A M, Schellhammer P F
Department of Radiation Oncology, Eastern Virginia Medical School, Norfolk.
Oncology (Williston Park). 1993 Feb;7(2):29-38; discussion 40, 43-4, 47.
Over the last 2 decades, the prognostic significance of post-irradiation prostate biopsy has been debated. Studies with long-term follow-up have shown a predictive effect with regard to local tumor failure and disease-free survival. More recently collected data involve the use of prostate ultrasound and prostate-specific antigen; the latter appears to be a good prognostic indicator on its own. Currently, the practical usefulness of post-treatment biopsy for clinically undetectable disease remains undefined, since definitive therapy for positive findings cannot be widely applied, carries significant morbidity, and, as yet, is of questionable benefit. Further study is certainly necessary, and it is perhaps under these conditions that this post-therapy procedure should be used.
在过去20年里，放疗后前列腺活检的预后意义一直存在争议。长期随访研究表明，其对局部肿瘤复发和无病生存期具有预测作用。最近收集的数据涉及前列腺超声和前列腺特异性抗原的应用；后者本身似乎是一个良好的预后指标。目前，对于临床无法检测到的疾病，治疗后活检的实际效用仍不明确，因为对阳性结果的确定性治疗无法广泛应用，会带来显著的发病率，且目前其益处也存在疑问。进一步的研究当然是必要的，也许正是在这些条件下才应采用这种治疗后程序。
