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IL-1 beta-induced inhibition of beta-cell function is mediated through nitric oxide.

作者信息

Xenos E S, Stevens R B, Gores P F, Casanova D, Farney A C, Sutherland D E, Platt J L

机构信息

Department of Surgery, University of Minnesota, Minneapolis 55455.

出版信息

Transplant Proc. 1993 Feb;25(1 Pt 2):994.

PMID:7680174
Abstract
摘要

相似文献

1
IL-1 beta-induced inhibition of beta-cell function is mediated through nitric oxide.白细胞介素-1β诱导的β细胞功能抑制是通过一氧化氮介导的。
Transplant Proc. 1993 Feb;25(1 Pt 2):994.
2
Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase.白细胞介素-1β诱导离体大鼠胰岛产生一氧化氮需要基因转录,且可能导致三羧酸循环酶乌头酸酶受到抑制。
Endocrinology. 1991 Dec;129(6):3167-73. doi: 10.1210/endo-129-6-3167.
3
Reversibility of interleukin-1 beta-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase.通过抑制一氧化氮合酶实现白细胞介素-1β诱导的胰岛破坏和功能障碍的可逆性
Biochem J. 1994 May 1;299 ( Pt 3)(Pt 3):719-24. doi: 10.1042/bj2990719.
4
Nitric oxide mediates IL-1 beta-induced islet dysfunction and destruction: prevention by dexamethasone.一氧化氮介导白细胞介素-1β诱导的胰岛功能障碍和破坏:地塞米松的预防作用。
Autoimmunity. 1993;15(2):145-53. doi: 10.3109/08916939309043889.
5
Interrelationship of changes in islet nicotine adeninedinucleotide, insulin secretion, and cell viability induced by interleukin-1 beta.白细胞介素-1β诱导的胰岛烟酰胺腺嘌呤二核苷酸变化、胰岛素分泌及细胞活力之间的相互关系。
Endocrinology. 1994 Feb;134(2):537-42. doi: 10.1210/endo.134.2.7507826.
6
A 1-hour pulse with IL-1 beta induces formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans: evidence for a tyrosine kinase signaling mechanism.白细胞介素-1β作用1小时可诱导大鼠胰岛产生一氧化氮并抑制胰岛素分泌:酪氨酸激酶信号传导机制的证据。
FASEB J. 1993 Feb 1;7(2):369-74. doi: 10.1096/fasebj.7.2.8440413.
7
Nitric oxide and cyclic GMP formation induced by interleukin 1 beta in islets of Langerhans. Evidence for an effector role of nitric oxide in islet dysfunction.白细胞介素1β在胰岛中诱导一氧化氮和环磷酸鸟苷生成。一氧化氮在胰岛功能障碍中起效应作用的证据。
Biochem J. 1992 Oct 1;287 ( Pt 1)(Pt 1):229-35. doi: 10.1042/bj2870229.
8
Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.白细胞介素-1β诱导胰岛中可通过电子顺磁共振检测到的铁-亚硝基复合物的形成。一氧化氮在白细胞介素-1β诱导的胰岛素分泌抑制中的作用。
J Biol Chem. 1991 Nov 15;266(32):21351-4.
9
IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide.白细胞介素-1β诱导胰岛同时共表达一氧化氮合酶和环氧化酶:一氧化氮对环氧化酶的激活作用。
Biochemistry. 1993 Dec 21;32(50):13767-70. doi: 10.1021/bi00213a002.
10
Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide.白细胞介素1β可诱导从啮齿动物胰岛中纯化的β细胞生成一氧化氮。证据表明β细胞是一氧化氮的来源和作用部位。
J Clin Invest. 1992 Dec;90(6):2384-91. doi: 10.1172/JCI116129.

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Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function.急性细胞因子介导的锌转运体 ZnT8 的下调改变了胰岛β细胞的功能。
J Endocrinol. 2010 Aug;206(2):159-69. doi: 10.1677/JOE-09-0420. Epub 2010 May 27.
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Clinical islet cell transplantation. Are we there yet?临床胰岛细胞移植。我们成功了吗?
Int J Pancreatol. 1998 Dec;24(3):145-68. doi: 10.1007/BF02788418.