Wolf S, Schulte-Strake U, Bertram B, Schulte K, Arend O, Reim M
Augenklinik, Medizinische Fakultät der RWTH, Aachen.
Ophthalmologe. 1993 Feb;90(1):21-6.
A prospective study was performed in 22 patients with an anterior ischaemic optic neuropathy (AION). All patients underwent iso- (Hct > or = 42%) or hypervolemic (Hct < 42%) haemodilution for 10 days with daily infusion of 250 ml hydroxyethyl starch (MW 200,000/0.5, 10% HAES-sterile) in combination with pentoxifylline (p.o.: 1200 mg/day; i.v.: 300 mg/day; Trental). Only patients with recent AION (less than 2 weeks' duration of symptoms) were considered for the prospective trial. Clinical, haemodynamic (arterio-venous passage time) and rheological (haematocrit, plasma viscosity, erythrocyte aggregation) data of all patients were recorded before therapy and after 10 days. An improvement of central vision by 2 or more lines was seen in 7 patients after 10 days. Initially the arterio-venous passage time was significantly prolonged in patients (2.42 +/- 0.7 s) with AION compared with healthy volunteers (1.45 +/- 0.4 s). After the 10-day trial arterio-venous passage time was significantly shorter than baseline values. In addition, the initially elevated plasma viscosity (1.33 +/- 0.1 mPa) was significantly lowered by haemodilution therapy.
对22例前部缺血性视神经病变（AION）患者进行了一项前瞻性研究。所有患者均接受等容（血细胞比容≥42%）或高容（血细胞比容<42%）血液稀释10天，每日输注250毫升羟乙基淀粉（分子量200,000/0.5，10%贺斯无菌），并联合己酮可可碱（口服：1200毫克/天；静脉注射：300毫克/天；曲克芦丁）。只有近期发生AION（症状持续时间少于2周）的患者才被纳入该前瞻性试验。记录了所有患者治疗前和10天后的临床、血流动力学（动静脉通过时间）和流变学（血细胞比容、血浆粘度、红细胞聚集）数据。10天后，7例患者的中心视力提高了2行或更多。最初，AION患者的动静脉通过时间（2.42±0.7秒）与健康志愿者（1.45±0.4秒）相比显著延长。10天试验后，动静脉通过时间明显短于基线值。此外，血液稀释疗法使最初升高的血浆粘度（1.33±0.1毫帕）显著降低。
