Deonna T, Ziegler A L, Moura-Serra J, Innocenti G
Service de Pédiatrie, Unité de Neuropédiatrie, CHUV, Lausanne, Switzerland.
Dev Med Child Neurol. 1993 Feb;35(2):166-76. doi: 10.1111/j.1469-8749.1993.tb11619.x.
The authors report a follow-up study of two boys who presented with autistic regression (after normal early development) at 13 and 22 months. Both were found on cerebral imaging to have tuberous sclerosis, with lesions involving the limbic system, bilaterally in the second child. The first child's regression coincided with the onset of partial complex seizures; disappearance of the autistic behaviour and marked improvement in cognitive development occurred with remission of the epilepsy. The second child, who had probable seizures and a late-appearing epileptic focus on EEG, remained severely disabled. The autistic behaviour appears to be linked to pathology in the limbic system and a direct role of epilepsy in the regression is proposed.
作者报告了一项对两名男孩的随访研究，这两名男孩分别在13个月和22个月时出现了孤独症退化（早期发育正常之后）。脑部影像学检查发现两人均患有结节性硬化症，其中第二名儿童双侧边缘系统有病变。第一名儿童的退化与部分复杂性癫痫发作的开始同时出现；随着癫痫缓解，孤独症行为消失，认知发展显著改善。第二名儿童可能有癫痫发作，脑电图上有迟发性癫痫病灶，仍然严重残疾。孤独症行为似乎与边缘系统的病变有关，并提出癫痫在退化过程中起直接作用。
