Campagnoni A T, Pribyl T M, Campagnoni C W, Kampf K, Amur-Umarjee S, Landry C F, Handley V W, Newman S L, Garbay B, Kitamura K
Mental Retardation Research Center, UCLA School of Medicine 90024.
J Biol Chem. 1993 Mar 5;268(7):4930-8.
We have identified a novel transcription unit of 105 kilobases (called the Golli-mbp gene) that encompasses the mouse myelin basic protein (MBP) gene. Three unique exons within this gene are alternatively spliced into MBP exons and introns to produce a family of MBP gene-related mRNAs that are under individual developmental regulation. These mRNAs are temporally expressed within cells of the oligodendrocyte lineage at progressive stages of differentiation. Thus, the MBP gene is a part of a more complex gene structure, the products of which may play a role in oligodendrocyte differentiation prior to myelination. One Golli-mbp mRNA that encodes a protein antigenically related to MBP is also expressed in the spleen and other non-neural tissues.
我们鉴定出一个105千碱基的新转录单元（称为Golli-mbp基因），它包含小鼠髓鞘碱性蛋白（MBP）基因。该基因内的三个独特外显子可选择性剪接成MBP外显子和内含子，以产生一系列受个体发育调控的MBP基因相关mRNA。这些mRNA在少突胶质细胞谱系细胞分化的不同阶段在特定时间表达。因此，MBP基因是一个更复杂基因结构的一部分，其产物可能在髓鞘形成之前的少突胶质细胞分化中发挥作用。一种编码与MBP抗原相关蛋白质的Golli-mbp mRNA也在脾脏和其他非神经组织中表达。
