Inoue T, Koyama T, Yamashita I
Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, Japan.
Pharmacol Biochem Behav. 1993 Feb;44(2):371-4. doi: 10.1016/0091-3057(93)90476-a.
The effects of electric foot-shock stress (EFS) and conditioned fear stress (CFS) on serotonin [5-hydroxytryptamine (5-HT)] metabolism in seven various brain regions of the rat were studied by measuring tryptophan, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA). EFS for 30 min increased tryptophan levels in almost all brain regions but did not change 5-HT levels in any regions. It increased 5-HIAA levels in the medial prefrontal cortex (mPFC), nucleus accumbens, and amygdala. CFS (exposure to an environment paired previously with foot-shock) increased defecation and induced freezing behavior. It failed to change tryptophan and 5-HT levels in any brain regions but increased 5-HIAA level only in the mPFC. In contrast to EFS, which increased 5-HT metabolism in several other brain regions, increased metabolism of 5-HT was especially marked in the mPFC after CFS, regarded as psychological stress.
通过测量色氨酸、5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA），研究了电足部电击应激（EFS）和条件性恐惧应激（CFS）对大鼠七个不同脑区5-羟色胺[5-羟色胺（5-HT）]代谢的影响。30分钟的EFS增加了几乎所有脑区的色氨酸水平，但未改变任何区域的5-HT水平。它增加了内侧前额叶皮质（mPFC）、伏隔核和杏仁核中的5-HIAA水平。CFS（暴露于先前与足部电击配对的环境）增加了排便并诱发了僵住行为。它未能改变任何脑区的色氨酸和5-HT水平，但仅在mPFC中增加了5-HIAA水平。与在其他几个脑区增加5-HT代谢的EFS相反，CFS（被视为心理应激）后mPFC中5-HT的代谢增加尤为明显。
