PIG-A的克隆，PIG-A是糖基磷脂酰肌醇（GPI）锚生物合成早期步骤中的一个成分。
The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis.
作者信息
Miyata T, Takeda J, Iida Y, Yamada N, Inoue N, Takahashi M, Maeda K, Kitani T, Kinoshita T
机构信息
Department of Immunoregulation, Osaka University, Japan.
出版信息
Science. 1993 Feb 26;259(5099):1318-20. doi: 10.1126/science.7680492.
The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic pathway. A complementary DNA encoding a human protein termed PIG-A (phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
糖基磷脂酰肌醇（GPI）锚是许多蛋白质的膜附着结构，存在于从酵母到哺乳动物的多种真核生物中。GPI锚核心结构在原生动物和哺乳动物中是保守的，其生物合成途径也是如此。编码一种称为PIG-A（磷脂酰肌醇聚糖A类）的人类蛋白质的互补DNA被克隆出来。PIG-A是N-乙酰葡糖胺基磷脂酰肌醇合成所必需的，N-乙酰葡糖胺基磷脂酰肌醇是GPI锚生物合成中非常早期的中间体。
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