Jones R S
University Department of Pharmacology, University of Oxford, UK.
Trends Neurosci. 1993 Feb;16(2):58-64. doi: 10.1016/0166-2236(93)90018-h.
On the basis of neuroanatomical studies, the entorhinal cortex (EC) has long been regarded as a relay station that provides the major source of afferent input to the hippocampus. The perforant path input to the dentate gyrus from layer II has traditionally been regarded as the major pathway by which information is transferred. However, electrophysiological studies are now indicating that other elements of the perforant path that project directly to CA1 and CA3 are more important than thought previously, and that the properties of different neuronal elements in the EC may determine the way in which information is passed on to and processed by the hippocampus. This article summarizes some of the properties of synaptic transmission in the EC and speculates on how frequency-dependent changes in transmission may be involved in the pre- and post-processing of hippocampal information by the EC.
基于神经解剖学研究，内嗅皮质（EC）长期以来一直被视为一个中继站，它是海马体传入输入的主要来源。传统上，从第二层到齿状回的穿通通路输入被视为信息传递的主要途径。然而，现在的电生理研究表明，直接投射到CA1和CA3的穿通通路的其他成分比以前认为的更重要，并且内嗅皮质中不同神经元成分的特性可能决定信息传递到海马体并由其处理的方式。本文总结了内嗅皮质中突触传递的一些特性，并推测传递中频率依赖性变化可能如何参与内嗅皮质对海马体信息的预处理和后处理。
