Baranger L, Gardembas M, Hillion J, Foussard C, Ifrah N, Boasson M, Berger R
Laboratoire de Génétique, CHU Angers, France.
Genes Chromosomes Cancer. 1993 Feb;6(2):118-20. doi: 10.1002/gcc.2870060209.
Acute promyelocytic leukemia (APL) is usually associated with the translocation t(15;17)(q22;q12-21), which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a patient with typical APL without the common t(15;17). Cytogenetic studies demonstrated a normal appearance of chromosomes 15, while a small marker seemed to be an i(17q-). Molecular analysis showed RARA and PML rearrangements, suggesting that the chromosome abnormality corresponded to a variant translocation.
