血小板衍生的伤口愈合配方在损伤脊髓中促进体内血管生成。

In vivo angiogenesis by platelet-derived wound-healing formula in injured spinal cord.

作者信息

Hiraizumi Y, Transfeldt E E, Kawahara N, Sung J H, Knighton D, Fiegel V D

机构信息

Department of Orthopaedic Surgery, University of Minnesota, Minneapolis 55455.

出版信息

Brain Res Bull. 1993;30(3-4):353-7. doi: 10.1016/0361-9230(93)90264-c.

DOI:10.1016/0361-9230(93)90264-c

PMID:7681352

Abstract

In vivo angiogenesis was investigated using platelet-derived wound-healing formula (PDWHF) in the injured cat spinal cord. Twenty-two gauge teflon sheaths, which had been coated with PDWHF-Hydron or only with Hydron, were inserted into the spinal cords of cats and the injured cats were maintained for 3 weeks. Selection of PDWHF-Hydron or Hydron was double blinded. The PDWHF-Hydron group showed notable neovascularization as well as dilation around the injury site, and this was statistically significant when compared to the control group. PDWHF seems to play a role in the healing processes of spinal cord injury and may have important interactions with other growth factors and in particular neurogenic growth factor.

摘要

在受伤的猫脊髓中，使用血小板衍生伤口愈合配方（PDWHF）研究体内血管生成。将涂有PDWHF - Hydron或仅涂有Hydron的22号聚四氟乙烯鞘管插入猫的脊髓中，并将受伤的猫饲养3周。PDWHF - Hydron或Hydron的选择采用双盲法。PDWHF - Hydron组在损伤部位周围显示出明显的新血管形成以及扩张，与对照组相比，这具有统计学意义。PDWHF似乎在脊髓损伤的愈合过程中发挥作用，并且可能与其他生长因子，特别是神经源性生长因子有重要的相互作用。