Long M, Langley C H
Section of Genetics, University of California, Davis 95616.
Science. 1993 Apr 2;260(5104):91-5. doi: 10.1126/science.7682012.
The origin of new genes includes both the initial molecular events and subsequent population dynamics. A processed Drosophila alcohol dehydrogenase (Adh) gene, previously thought to be a pseudogene, provided an opportunity to examine the two phases of the origin of a new gene. The sequence of the processed Adh messenger RNA became part of a new functional gene by capturing several upstream exons and introns of an unrelated gene. This novel chimeric gene, jingwei, differs from its parent Adh gene in both its pattern of expression and rate of molecular evolution. Natural selection participated in the origin and subsequent evolution of this gene.
新基因的起源包括最初的分子事件和随后的群体动态。一个经过加工的果蝇乙醇脱氢酶（Adh）基因，以前被认为是一个假基因，为研究新基因起源的两个阶段提供了一个机会。经过加工的Adh信使核糖核酸的序列通过捕获一个不相关基因的几个上游外显子和内含子，成为一个新的功能基因的一部分。这个新的嵌合基因“经纬”，在表达模式和分子进化速率上都与其亲本Adh基因不同。自然选择参与了这个基因的起源和随后的进化。
