犬载脂蛋白H（β2-糖蛋白I）的特性及急性期调节

Characterization and acute phase modulation of canine apolipoprotein H (beta 2-glycoprotein I).

作者信息

Sellar G C, Keane J, Mehdi H, Peeples M E, Browne N, Whitehead A S

机构信息

Department of Genetics, Trinity Biotechnology Institute, Trinity College, Dublin, Ireland.

出版信息

Biochem Biophys Res Commun. 1993 Mar 31;191(3):1288-93. doi: 10.1006/bbrc.1993.1357.

DOI:10.1006/bbrc.1993.1357

PMID:7682067

Abstract

Apolipoprotein H (ApoH) is a 50 kDa glycoprotein capable of binding to negatively charged phospholipids and is a probable inhibitor of the blood coagulation pathway, platelet aggregation, and platelet prothrombinase activity, as well as being involved in autoimmune disease. We have cloned and sequenced a full length ApoH cDNA clone from a beagle dog liver library. Its derived amino acid sequence shows high cross-species similarity to ApoH from other mammals. Canine ApoH mRNA expression is down regulated during an experimentally induced inflammatory response establishing that it is a negative acute phase reactant.

摘要

载脂蛋白H（ApoH）是一种50 kDa的糖蛋白，能够与带负电荷的磷脂结合，可能是血液凝固途径、血小板聚集和血小板凝血酶原酶活性的抑制剂，并且参与自身免疫性疾病。我们已经从比格犬肝脏文库中克隆并测序了一个全长ApoH cDNA克隆。其推导的氨基酸序列与其他哺乳动物的ApoH具有高度的跨物种相似性。在实验诱导的炎症反应期间，犬ApoH mRNA表达下调，表明它是一种负急性期反应物。