Gerl A, Clemm C, Salat C, Mittermüller J, Bomfleur W, Wilmanns W
Medizinische Klinik III, Ludwig-Maximilians-Universität München, Germany.
Cancer. 1993 May 1;71(9):2838-40. doi: 10.1002/1097-0142(19930501)71:9<2838::aid-cncr2820710926>3.0.co;2-i.
Although testicular cancer and Hodgkin disease are the neoplasms with the highest incidence in young men, only 13 cases of metachronous and 2 cases of synchronous occurrence in the same person were reported before 1991.
A 30-year-old man is described, in whom, 2 years after radiation therapy for Stage IIIA Hodgkin disease, a testicular nonseminomatous germ cell tumor developed with metastatic spread to the retroperitoneal lymph nodes, lung, and left supraclavicular fossa. The second case report describes a 31-year-old man in whom a metastasizing nonseminomatous testicular cancer, with elevation of levels of the serum tumor markers alpha-fetoprotein and human chorionic gonadotropin, developed simultaneously with axillary lymphadenopathy that was histologically confirmed Hodgkin disease.
After five cycles of cisplatin-based chemotherapy and secondary retroperitoneal lymphadenectomy, the patient with metachronous disease has remained in complete remission for 8 years. The patient with synchronous occurrence has been disease-free for 14 months after five cycles of chemotherapy consisting of cisplatin, etoposide, and doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH).
The metachronous and synchronous occurrence of testicular cancer and Hodgkin disease is a rare association of two curable neoplasms. The presence of both malignant neoplasms should be taken into consideration in young male patients, especially if disease distribution diverges from a regular pattern.
尽管睾丸癌和霍奇金病是年轻男性中发病率最高的肿瘤，但在1991年之前，仅报告过13例异时性和2例同一人同时发生的病例。
描述了一名30岁男性，在接受IIIA期霍奇金病放疗2年后，发生了睾丸非精原细胞瘤性生殖细胞肿瘤，并转移至腹膜后淋巴结、肺和左锁骨上窝。第二例报告描述了一名31岁男性，其转移性非精原细胞瘤性睾丸癌伴有血清肿瘤标志物甲胎蛋白和人绒毛膜促性腺激素水平升高，与经组织学证实为霍奇金病的腋窝淋巴结病同时发生。
接受基于顺铂的化疗五个周期并进行二期腹膜后淋巴结清扫术后，异时性疾病患者已完全缓解8年。同时发生疾病的患者在接受由顺铂、依托泊苷和阿霉素（阿霉素，阿德里亚实验室，俄亥俄州哥伦布）组成的化疗五个周期后，已无病生存14个月。
睾丸癌和霍奇金病的异时性和同时性发生是两种可治愈肿瘤的罕见关联。在年轻男性患者中，尤其是疾病分布与常规模式不同时，应考虑两种恶性肿瘤同时存在的情况。
