Zernig G, Troger J, Saria A
Department of Psychiatry, University of Innsbruck, Austria.
Neurosci Lett. 1993 Mar 5;151(1):64-6. doi: 10.1016/0304-3940(93)90046-n.
The non-peptide NK1 antagonists, RP 67580, and (2S,3S)-CP-96,345, the NK1 receptor-selective enantiomer of the racemic compound, were tested in Swiss albino mice in the black-and-white box behavioral paradigm. Both qualitatively and quantitatively, (2S,3S)-CP-96,345 produced the same behavioral effects as the racemic compound. In contrast, RP 67580 decreased exploratory behavior only in the white section, whereas crossings and rearings in the black section were not changed. In addition, RP 67580 decreased transitions. While the observed changes induced by CP-96,345 are caused by sedation and motor impairment, the effects of RP 67580 might be due to sedation plus an additional anxiogenic effect.
非肽类NK1拮抗剂RP 67580以及外消旋化合物的NK1受体选择性对映体(2S,3S)-CP-96,345，在瑞士白化小鼠的黑白箱行为范式中进行了测试。无论在定性还是定量方面，(2S,3S)-CP-96,345产生的行为效应都与外消旋化合物相同。相比之下，RP 67580仅在白色区域减少了探究行为，而黑色区域的穿越和直立行为没有改变。此外，RP 67580减少了转换行为。虽然CP-96,345引起的观察到的变化是由镇静和运动损伤导致的，但RP 67580的效应可能是由于镇静加上额外的致焦虑效应。
