前列腺子宫内膜样癌。Leu7和前列腺特异性抗原的诊断价值。

Endometrioid carcinoma of the prostate. The diagnostic value of Leu7 and prostatic specific antigen.

作者信息

Stavropoulos N E, Ioackim-Velogianni E, Sidoni K, Stefanou D, Klouvas G, Pavlidis N

机构信息

Department of Urology, University of Ioannina, Greece.

出版信息

Br J Urol. 1993 Mar;71(3):309-12. doi: 10.1111/j.1464-410x.1993.tb15948.x.

DOI:10.1111/j.1464-410x.1993.tb15948.x

PMID:7682888

Abstract

In a case of endometrioid carcinoma of the prostate the expression of Leu7 and prostatic specific antigen (PSA) was studied immunohistochemically on paraffin sections. The same markers were studied in 14 cases of prostatic cancer and 14 cases of uterine endometrial carcinoma. Endometrioid carcinoma of the prostate was negative for Leu7 and PSA, while all prostatic cancer specimens were positive for the above markers. All uterine endometrial carcinomas were negative for PSA and only a small percentage of cells in 4 specimens were positive for Leu7. The absence of Leu7 and PSA in this case of endometrioid carcinoma strongly suggests a müllerian origin.

摘要

在一例前列腺子宫内膜样癌中，采用免疫组织化学方法在石蜡切片上研究了Leu7和前列腺特异性抗原（PSA）的表达。在14例前列腺癌和14例子宫内膜癌中研究了相同的标志物。前列腺子宫内膜样癌Leu7和PSA呈阴性，而所有前列腺癌标本上述标志物均呈阳性。所有子宫内膜癌PSA呈阴性，仅4例标本中有一小部分细胞Leu7呈阳性。该例子宫内膜样癌中Leu7和PSA的缺失强烈提示其起源于苗勒管。