Scheffer J, König W
Lehrstuhl für Medizinische Mikrobiologie und Immunologie, Ruhr-Universität Bochum, BRD.
Respiration. 1993;60 Suppl 1:25-31. doi: 10.1159/000196246.
The oral cephalosporins cefaclor, cefetamet, Ro 40-6890 and cefpodoxime were studied with regard to their effects to modulate the chemiluminescence response, the rate of phagocytosis, bactericidal action and leukotriene formation from human granulocytes, the release of histamine from human basophils and the induction and release of tumor necrosis factor (TNF) and interleukin-6 (IL-6) from a preparation of human lymphocytes, monocytes and basophils. The cephalosporins increased the histamine release induced by Escherichia coli and Staphylococcus aureus whereas the synthesis of leukotrienes from human neutrophils was decreased. The studies with regard to adherence and phagocytosis showed a significant increase in phagocytosis for E. coli. The bactericidal activity of human granulocytes was also enhanced. Furthermore, the studied cephalosporins decreased the release of IL-6 and TNF.
对口服头孢菌素头孢克洛、头孢他美、Ro 40-6890和头孢泊肟进行了研究，观察它们对以下方面的影响：调节化学发光反应、吞噬作用速率、杀菌作用以及人粒细胞中白三烯的形成、人嗜碱性粒细胞中组胺的释放，以及人淋巴细胞、单核细胞和嗜碱性粒细胞制剂中肿瘤坏死因子（TNF）和白细胞介素-6（IL-6）的诱导和释放。头孢菌素增加了由大肠杆菌和金黄色葡萄球菌诱导的组胺释放，而人中性粒细胞中白三烯的合成减少。关于黏附和吞噬作用的研究表明，对大肠杆菌的吞噬作用显著增加。人粒细胞的杀菌活性也得到增强。此外，所研究的头孢菌素减少了IL-6和TNF的释放。
