Maher E J, Timothy A, Squire C J, Goodman A, Karp S J, Paine C H, Ryall R, Read G
Audit Working Party on behalf of the Faculty of Oncology, Royal College of Radiologists, London, UK.
Clin Oncol (R Coll Radiol). 1993;5(2):72-9. doi: 10.1016/s0936-6555(05)80850-7.
A questionnaire on the management of NSCLC was sent to all clinical oncologists in the UK. Responses were received from 121 individuals with at least one representative response from each of 54 British radiotherapy units. Results were then discussed at an open meeting attended by a cross section of clinical oncologists; a synopsis of responses to the questionnaire and discussion at this meeting is contained in this report. A majority of respondents estimated treatment of NSCLC to make up 10%-25% of their work-load. Radical and palliative treatments could be clearly distinguished, and aims of treatment, selection criteria and radiotherapy schedules were consistent with recommendations in the published literature. More than 90% of treatments were with palliative rather than radical intent. Radical treatment schedules could be divided according to dose (< 50 Gy, 50-55 Gy and >55 Gy), number of fractions (< 20, 20, > 20 fractions), overall time < 4/52, 4/52, > 4/52), dose per fraction (> 2.75 Gy, 2.1-2.75 Gy, < or = 2 Gy) and target volume (tumour alone, tumour and hilar nodes, or tumour, hilar and mediastinal nodes). Divided thus, radical techniques fell into three broad groups, each of the three techniques supported by a body of literature. Choice of schedule could be related to a heterogeneous referral pattern and unresolved controversies, identified as debate on the value of treating mediastinal lymphadenopathy with high dose radiation, the value of 'subradical doses' of radiation for microscopic disease, and the relative importance of volume treated, total dose, dose per fraction and overall treatment time in achieving an optimal therapeutic ratio.(ABSTRACT TRUNCATED AT 250 WORDS)
一份关于非小细胞肺癌(NSCLC)治疗管理的调查问卷被发送给了英国所有的临床肿瘤学家。共收到了121份回复,其中来自54个英国放疗单位,每个单位至少有一份代表性回复。随后,在一次由各领域临床肿瘤学家参加的公开会议上对结果进行了讨论;本报告包含了对调查问卷的回复摘要以及此次会议上的讨论内容。大多数受访者估计,NSCLC的治疗占其工作量的10%-25%。根治性治疗和姑息性治疗能够被清晰区分,治疗目的、选择标准和放疗方案与已发表文献中的建议一致。超过90%的治疗是姑息性而非根治性目的。根治性治疗方案可根据剂量(<50 Gy、50-55 Gy和>55 Gy)、分次剂量(<20次、20次、>20次)、总疗程时间(<4/52、4/52、>4/52)、每次分割剂量(>2.75 Gy、2.1-2.75 Gy、≤2 Gy)以及靶区体积(仅肿瘤、肿瘤及肺门淋巴结或肿瘤、肺门及纵隔淋巴结)进行分类。如此划分后,根治性技术可分为三大类,每类技术都有相应的文献支持。治疗方案的选择可能与转诊模式的多样性以及尚未解决的争议有关,这些争议包括高剂量放疗治疗纵隔淋巴结肿大的价值、针对微小病灶的“次根治剂量”放疗的价值,以及在实现最佳治疗比方面,靶区体积、总剂量、每次分割剂量和总治疗时间的相对重要性。(摘要截选至250词)