Colado M I, Ormazabal M J, Alfaro M J, Martin M I
Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
J Pharm Pharmacol. 1993 Mar;45(3):220-2. doi: 10.1111/j.2042-7158.1993.tb05537.x.
The effects of Bay K 8644 (1, 2 and 4 mg kg-1, i.p.) on the synthesis and metabolism of dopamine and 5-hydroxytryptamine (5-HT) in rat brain after m-hydroxybenzylhydrazine administration were studied. Bay K 8644 (2 and 4 mg kg-1, i.p.) caused an increase in the synthesis of both dopamine in the striatum and 5-HT in the midbrain and striatum, measured as the accumulation of 3,4-dihydroxyphenylalanine (dopa) and 5-hydroxytryptophan, respectively. Moreover, Bay K 8644 at the dose of 4 mg kg-1 increased the turnover of dopamine in the striatum and of 5-HT in midbrain and striatum. These neurochemical changes were antagonized by the calcium channel antagonist nimodipine (10 mg kg-1, i.p.). It is concluded that dihydropyridine receptors may mediate the brain region-specific changes in the dopaminergic and 5-HT-ergic neurotransmission which occur following activation of neuronal calcium channels.
研究了 Bay K 8644（腹腔注射，剂量为 1、2 和 4 mg·kg⁻¹）对间羟基苄基肼给药后大鼠脑内多巴胺和 5-羟色胺（5-HT）合成及代谢的影响。Bay K 8644（腹腔注射，剂量为 2 和 4 mg·kg⁻¹）分别导致纹状体中多巴胺和中脑及纹状体中 5-HT 的合成增加，这可通过 3,4-二羟基苯丙氨酸（多巴）和 5-羟色氨酸的积累来衡量。此外，4 mg·kg⁻¹ 剂量的 Bay K 8644 增加了纹状体中多巴胺以及中脑和纹状体中 5-HT 的周转。这些神经化学变化被钙通道拮抗剂尼莫地平（腹腔注射，10 mg·kg⁻¹）所拮抗。得出的结论是，二氢吡啶受体可能介导了神经元钙通道激活后发生的多巴胺能和 5-HT 能神经传递中脑区特异性变化。
