Heilmann L, von Tempelhoff G F
Abtl. Gynäkologie und Geburtshilfe, Stadtkrankenhaus Rüsselsheim.
Z Geburtshilfe Perinatol. 1993 Jan-Feb;197(1):43-7.
In a double-blind study, 12 patients with an Hb > 13 g/dl in the second trimester, a pretherapeutic hematocrit > 38%, and a fetal aortal resistance index > 0.75 underwent hemodilution. The patients were given either 500 ml hydroxyethyl starch (HAES) or 500 ml NaCl 0.9%. In addition, all patients received 500 ml NaCl 0.9% by infusion. HAES therapy caused a lowering of the fetal aortal and uterine artery resistance indices. This was not the case with NaCl. The causes for this lie in the specific anti-aggregation and viscosity-reducing effect of hydroxyethyl starch with an identical lowering of hematocrit.
在一项双盲研究中，12例孕中期血红蛋白>13 g/dl、治疗前血细胞比容>38%且胎儿主动脉阻力指数>0.75的患者接受了血液稀释。这些患者被给予500毫升羟乙基淀粉（HAES）或500毫升0.9%氯化钠溶液。此外，所有患者均通过静脉输注接受500毫升0.9%氯化钠溶液。HAES治疗导致胎儿主动脉和子宫动脉阻力指数降低。氯化钠治疗则未出现这种情况。其原因在于羟乙基淀粉具有特定的抗聚集和降低粘度的作用，同时血细胞比容也有相同程度的降低。
