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IGFBP-2: an important regulator of insulin-like growth factor action in human lung tumours?

作者信息

Reeve J G, Schwander J, Bleehen N M

机构信息

Medical Research Council Clinical Oncology and Radiotherapeutics Unit, Medical Research Council Centre, Cambridge, UK.

出版信息

Growth Regul. 1993 Mar;3(1):82-4.

PMID:7683542
Abstract
摘要

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Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5, and 6: synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells.雌激素受体阴性人乳腺癌细胞中胰岛素样生长因子结合蛋白-1、2、3、4、5和6的调节：合成、分泌及基因表达
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引用本文的文献

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Intracellular colocalization and interaction of IGF-binding protein-2 with the cyclin-dependent kinase inhibitor p21CIP1/WAF1 during growth inhibition.生长抑制过程中胰岛素样生长因子结合蛋白-2与细胞周期蛋白依赖性激酶抑制剂p21CIP1/WAF1的细胞内共定位及相互作用
Biochem J. 2005 Dec 15;392(Pt 3):457-65. doi: 10.1042/BJ20050517.
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Significant expression of IGFBP2 in breast cancer compared with benign lesions.与良性病变相比，IGFBP2在乳腺癌中表达显著。
J Clin Pathol. 2005 Apr;58(4):361-6. doi: 10.1136/jcp.2004.020834.
3
Protease-resistant form of insulin-like growth factor-binding protein 5 is an inhibitor of insulin-like growth factor-I actions on porcine smooth muscle cells in culture.
胰岛素样生长因子结合蛋白5的蛋白酶抗性形式是胰岛素样生长因子-I对培养的猪平滑肌细胞作用的抑制剂。
J Clin Invest. 1997 Nov 15;100(10):2596-605. doi: 10.1172/JCI119803.
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Bioactivity of glomerular ultrafiltrate during heavy proteinuria may contribute to renal tubulo-interstitial lesions: evidence for a role for insulin-like growth factor I.大量蛋白尿时肾小球超滤液的生物活性可能导致肾小管间质损伤：胰岛素样生长因子I作用的证据
J Clin Invest. 1996 Jul 1;98(1):116-24. doi: 10.1172/JCI118755.