Steiger M J, Tarnesby G, Gabe S, McLaughlin J, Schapira A H
Department of Neuroscience, Royal Free Hospital, London, United Kingdom.
Ann Neurol. 1993 Apr;33(4):407-11. doi: 10.1002/ana.410330415.
The prognosis of patients with progressive multifocal leukoencephalopathy is poor, with few patients showing remission or surviving. We describe a 37-year-old man who developed progressive multifocal leukoencephalopathy in association with sarcoidosis. Despite treatment with cytarabine and acyclovir, he continued to deteriorate. Shortly following the addition of interferon alfa, he made a dramatic improvement, regaining full functional independence. The use of interferon alfa in addition to cytarabine in such patients offers a new therapeutic approach worthy of further trial.
进行性多灶性白质脑病患者的预后较差，很少有患者能缓解或存活。我们描述了一名37岁的男性，他患进行性多灶性白质脑病并伴有结节病。尽管接受了阿糖胞苷和阿昔洛韦治疗，他的病情仍持续恶化。在加用干扰素α后不久，他病情显著改善，恢复了完全的功能独立。在此类患者中，除阿糖胞苷外加用干扰素α提供了一种值得进一步试验的新治疗方法。
