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The human Kell blood group gene maps to chromosome 7q33 and its expression is restricted to erythroid cells.

作者信息

Lee S, Zambas E D, Marsh W L, Redman C M

机构信息

Lindsley F. Kimball Research Institute, New York Blood Center, NY 10021.

出版信息

Blood. 1993 May 15;81(10):2804-9.

PMID:7683930
Abstract

The Kell blood group is one of the major antigenic systems in human red blood cells. To determine the location of the Kell gene on human chromosomes, panels containing genomic DNA of human-hamster somatic cell hybrids were hybridized with radiolabeled cDNA probe specific for the Kell locus. Only the samples containing DNA from chromosome 7 gave positive hybridization signals. In situ hybridization analysis, using genomic clones isolated with the cDNA, localized the KEL gene to 7q33. Northern blot analysis of poly(A)+ RNA from human brain, kidney, lung, fetal and adult liver, and bone marrow showed that Kell transcripts were only present in fetal liver and bone marrow. This indicates that the Kell protein, which carries the Kell antigens, may only be expressed in erythroid tissues.

摘要

相似文献

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The human Kell blood group gene maps to chromosome 7q33 and its expression is restricted to erythroid cells.
Blood. 1993 May 15;81(10):2804-9.
2
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Molecular cloning and primary structure of Kell blood group protein.凯尔血型蛋白的分子克隆及一级结构
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Expression of Kell blood group protein in nonerythroid tissues.凯尔血型蛋白在非红细胞组织中的表达。
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2
Anti-K1 (Kell) Antibody Expressed in Maternal Breastmilk: A Case Report of a Neonate with Multiple Intrauterine Transfusions and Postnatal Exposure to Kell Antibody in Maternal Breastmilk.母乳中表达的抗K1（凯尔）抗体：一例患有多次宫内输血及产后经母乳接触凯尔抗体的新生儿病例报告
Case Rep Pediatr. 2017;2017:6927813. doi: 10.1155/2017/6927813. Epub 2017 Mar 5.
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Genetic polymorphisms of Rh, Kell, Duffy and Kidd systems in a population from the State of Paraná, southern Brazil.
巴西南部巴拉那州人群中Rh、Kell、达菲和基德血型系统的基因多态性
Rev Bras Hematol Hemoter. 2011;33(1):21-5. doi: 10.5581/1516-8484.20110009.
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Another example of a KEL1 variant red cell phenotype due to a threonine to serine change at position 193 of Kell glycoprotein.另一个KEL1变异红细胞表型的例子，是由于凯尔糖蛋白第193位的苏氨酸变为丝氨酸所致。
Transfusion. 2008 May;48(5):925-9. doi: 10.1111/j.1537-2995.2007.01623.x. Epub 2008 Feb 1.
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Transcriptional regulation of the KEL gene and Kell protein expression in erythroid and non-erythroid cells.红系和非红系细胞中KEL基因的转录调控及凯尔蛋白表达
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