Kotovuori P, Tontti E, Pigott R, Shepherd M, Kiso M, Hasegawa A, Renkonen R, Nortamo P, Altieri D C, Gahmberg C G
Department of Biochemistry, University of Helsinki, Finland.
Glycobiology. 1993 Apr;3(2):131-6. doi: 10.1093/glycob/3.2.131.
Leukocyte adhesion involves at least three molecular families of adhesion proteins: the leukocyte integrins CD11/CD18, the intercellular adhesion molecules (ICAMs) and the carbohydrate-binding L-, E- and P-selectins. The intercellular adhesion molecules are well-known ligands for the CD11/CD18 integrins. We now show that E-selectin specifically binds to the sialyl Lex carbohydrate epitopes of leukocyte integrins. Thus, the different families of leukocyte adhesion molecules form an integrated adhesion network.
白细胞整合素CD11/CD18、细胞间黏附分子（ICAMs）以及结合碳水化合物的L-、E-和P-选择素。细胞间黏附分子是CD11/CD18整合素广为人知的配体。我们现在发现，E-选择素特异性结合白细胞整合素的唾液酸化路易斯碳水化合物表位。因此，不同家族的白细胞黏附分子形成了一个整合的黏附网络。
