Comparative effects of 7.5% NaCl in 6% Dextran 70 and 0.9% NaCl on cardiorespiratory parameters after cardiac output-controlled resuscitation from canine hemorrhagic shock.

We resuscitated severely hemorrhaged (mean arterial pressure at 40 mm Hg for 30 min) pentobarbital-anesthetized dogs to 120% of control cardiac output with 7.5% NaCl in 6% Dextran 70 (HSD) or 0.9% NaCl (IS) to compare the effects on hemodynamic and oxygen transport parameters. Hemodynamic parameters and oxygen delivery did not differ between groups. Oxygen consumption and oxygen extraction ratio tended to be higher, and mixed venous oxygen tension lower (P < 0.05) for HSD during the first hour of the postresuscitation period. Resuscitation of the HSD group required significantly less time (10.4 +/- 2.0 vs. 23.6 +/- 1.7 min; P < 0.01) and fluid volume (8.0 +/- 1.1 vs. 47.0 +/- 3.3 ml.kg-1; P < 0.01). We conclude that the resuscitation of hypovolemic dogs with HSD and IS to equivalent cardiac output results in identical improvements in hemodynamics and oxygen delivery but that HSD may provide a better oxygen supply/demand balance during the first hour postresuscitation.