Enokihara H, Koike T
Third Department of Internal Medicine, Dokkyo University School of Medicine.
Nihon Rinsho. 1993 Mar;51(3):605-12.
The biochemistry, the molecular biology and the biological activity of the eosinophil granule proteins, major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN) and eosinophil peroxidase (EPO) are reviewed. MBP is present in the core of the eosinophil granule and is toxic to parasite and host cells. ECP and EDN are proteins in the matrix of the granule and share sequence similarity and ribonuclease activity. These two proteins can provoke the Gordon phenomenon in rabbits and are toxic to parasites. EPO consists of two polypeptide and is a toxin for parasite and host cells with or without H2O2. The common characteristics of these proteins are their high isoelectric points and cytotoxic activities.
本文综述了嗜酸性粒细胞颗粒蛋白、主要碱性蛋白（MBP）、嗜酸性粒细胞阳离子蛋白（ECP）、嗜酸性粒细胞衍生神经毒素（EDN）和嗜酸性粒细胞过氧化物酶（EPO）的生物化学、分子生物学及生物活性。MBP存在于嗜酸性粒细胞颗粒的核心，对寄生虫和宿主细胞有毒性。ECP和EDN是颗粒基质中的蛋白质，具有序列相似性和核糖核酸酶活性。这两种蛋白可在兔体内引发戈登现象，对寄生虫有毒性。EPO由两条多肽组成，无论有无H2O2，对寄生虫和宿主细胞均为毒素。这些蛋白的共同特点是具有高的等电点和细胞毒性活性。
