Penn R D, Walser R, Kurtz D, Ackerman L
J Neurosurg. 1976 Apr;44(4):449-57. doi: 10.3171/jns.1976.44.4.0449.
Computer and photographic methods for producing subtractions of computerized axial tomographic (CAT) scans have been developed. By subtracting point for point a normal scan from one taken after intravenous infusion of contrast material, a picture of the contrast in the cerebral vessels is created. By this method, tumor size and degree of vascularity may be assessed. Furthermore, abnormalities in perfusion and changes in blood volume due to mass effects and edema may be detected. Subtracting scans should add to the diagnostic potential of CAT and provide a noninvasive way to study vascular changes in cerebral disease.
已开发出用于对计算机断层扫描（CAT）进行减影的计算机和摄影方法。通过逐点从静脉注射造影剂后进行的扫描中减去正常扫描，可生成脑血管造影图像。通过这种方法，可以评估肿瘤大小和血管化程度。此外，还可以检测到由于占位效应和水肿导致的灌注异常和血容量变化。减影扫描应能增强CAT的诊断潜力，并提供一种无创方法来研究脑部疾病中的血管变化。
